Eif2s1 - eukaryotic translation initiation factor 2, subunit 1 alpha Gene

Also Known as 35kDa; Eif2a; eIF2alpha; 0910001O23Rik; 2410026C18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13665

Summary

Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Eif2s1 Products (1)

mRNA	Protein	Name
NM_026114.3	NP_080390.1	eukaryotic translation initiation factor 2 subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15544353	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to UV	IDA IDA: Inferred from direct assay	12176355	MGI
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	11106749	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	27430620	MGI
involved in negative regulation of translational initiation in response to stress	IDA IDA: Inferred from direct assay	12176355	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	19139267	MGI
acts upstream of or within regulation of translational initiation in response to stress	IDA IDA: Inferred from direct assay	15937339	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11106749	MGI
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	27430620	MGI
acts upstream of or within translation	IDA IDA: Inferred from direct assay	10882126	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12388085	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	19861488	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12388085	MGI
is active in synapse	EXP EXP: Inferred from Experiment	16452087	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16452087	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 2 subunit 1	eIF-2-alpha eIF-2A eIF-2alpha eukaryotic translation initiation factor 2 subunit alpha eukaryotic translation initiation factor 2A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04254	EIF2S1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21851	Eif2s1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28368	Eif2s1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2s1	NCBI	NCBI:1965