Eif4ebp1 - eukaryotic translation initiation factor 4E binding protein 1 Gene

Also Known as 4e-bp1; PHAS-I

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13685

Summary

Enables eukaryotic initiation factor 4E binding activity. Involved in IRES-dependent translational initiation of linear mRNA. Acts upstream of or within cellular response to dexamethasone stimulus; Insulin Receptor signaling pathway; and negative regulation of translational initiation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; oocyte; pancreas tip epithelium; retina; and skeletal musculature. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Eif4ebp1 Products (1)

mRNA Protein Name
NM_007918.3 NP_031944.3 eukaryotic translation initiation factor 4E-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables eukaryotic initiation factor 4E binding IPI
IPI: Inferred from physical interaction
16142217 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7629182 MGI
Biological Process GO Annotation Evidence References Source
involved in IRES-dependent translational initiation of linear mRNA IDA
IDA: Inferred from direct assay
24553947 MGI
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17556672 MGI
acts upstream of or within insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
7629182 MGI
acts upstream of or within negative regulation of translational initiation IDA
IDA: Inferred from direct assay
16142217 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E-binding protein 1

  • eIF4E-binding protein 1

  • phosphorylated heat- and acid-stable protein regulated by insulin 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04277 EIF4EBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20227 Eif4ebp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26734 Eif4ebp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4ebp1 NCBI NCBI:1978