Epha8 - Eph receptor A8 Gene

Also Known as Eek; Hek3; mKIAA1459

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13842

Summary

Enables GPI-linked Ephrin Receptor activity and growth factor binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; neuron development; and positive regulation of phosphatidylinositol 3-kinase activity. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus. Located in neuron projection. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human EphA8 (EPH receptor A8). [provided by Alliance of Genome Resources, Apr 2022]

Epha8 Products (1)

mRNA Protein Name
NM_007939.2 NP_031965.2 ephrin type-A receptor 8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GPI-linked ephrin receptor activity IDA
IDA: Inferred from direct assay
9053851 MGI
enables ephrin receptor activity IDA
IDA: Inferred from direct assay
11416136 MGI
enables growth factor binding IPI
IPI: Inferred from physical interaction
22568954 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9053851 MGI
Biological Process GO Annotation Evidence References Source
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
9214628 MGI
acts upstream of or within cellular response to follicle-stimulating hormone stimulus IDA
IDA: Inferred from direct assay
23242526 MGI
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
9053851 MGI
involved in neuron projection development IDA
IDA: Inferred from direct assay
15782114 MGI
involved in neuron remodeling IDA
IDA: Inferred from direct assay
17875921 MGI
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15782114 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
11416136 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
10498895 MGI
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
10498895 MGI
involved in regulation of cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
11416136 MGI
involved in substrate-dependent cell migration IDA
IDA: Inferred from direct assay
17875921 MGI
Cellular Component GO Annotation Evidence References Source
located in neuron projection IDA
IDA: Inferred from direct assay
17875921 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9053851 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-A receptor 8

  • EPH- and ELK-related kinase

  • Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase)

  • tyrosine-protein kinase receptor EEK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112440 HZX-02-059 Inhibitor 99.40% Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-RS04432 EPHA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-RS20398 Epha8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26907 Epha8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epha8 NCBI NCBI:2046