2. Gene
  3. EPHA8 - EPH receptor A8 Gene

EPHA8 - EPH receptor A8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EEK; EK3; HEK3

Gene ID: 2046 | Gene type: protein coding

About EPHA8

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,563,489-22,603,595 (from NCBI)

This gene has 2 transcripts (splice variants), 130 orthologues and 53 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for Ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

EPHA8 Products(2)

mRNA Protein Name
NM_001006943.3 NP_001006944.1 ephrin type-A receptor 8 isoform 2 precursor
NM_020526.5 NP_065387.1 ephrin type-A receptor 8 isoform 1 precursor

EPHA8 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (31 - 204)

fn3

fn3: Fibronectin type III domain (330 - 419)

fn3

fn3: Fibronectin type III domain (439 - 524)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (543 - 632)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (635 - 892)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (934 - 992)

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  • 1005 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 8

EPH- and ELK-related kinase

Recombinant EPHA8 Proteins

Cat. No. Product Name Accession Purity
HY-P70337 EphA8 Protein, Human (HEK293, His) P29322 (E31-T542) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-146375 UniPR505 Antagonist / Unkown
HY-RS04432 EPHA8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EPHA8 VGNC VGNC:40410
Felis catus EPHA8 VGNC VGNC:80195
Macaca mulatta EPHA8 VGNC VGNC:72240
Rattus norvegicus EPHA8 RGD RGD:708543
Mus musculus EPHA8 MGD MGI:109378
Bos taurus EPHA8 VGNC VGNC:28538
Others EPHA8 NCBI