Ephx2 - epoxide hydrolase 2, cytoplasmic Gene

Also Known as CEH; SEH; sEP; Eph2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13850

Summary

Enables Epoxide Hydrolase activity. Involved in several processes, including Cholesterol homeostasis; epoxide metabolic process; and regulation of Cholesterol metabolic process. Predicted to be located in cytosol. Predicted to be active in peroxisome. Is expressed in several structures, including eye; heart; integumental system; nervous system; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (Epoxide Hydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ephx2 Products (4)

mRNA Protein Name
NM_001271402.1 NP_001258331.1 bifunctional epoxide hydrolase 2 isoform b
NM_001271403.1 NP_001258332.1 bifunctional epoxide hydrolase 2 isoform c precursor
NM_001271421.1 NP_001258350.1 bifunctional epoxide hydrolase 2 isoform d
NM_007940.4 NP_031966.2 bifunctional epoxide hydrolase 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables epoxide hydrolase activity IMP
IMP: Inferred from mutant phenotype
21217101 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
18974052 MGI
involved in epoxide metabolic process IMP
IMP: Inferred from mutant phenotype
21217101 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18974052 MGI
involved in regulation of cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
18974052 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional epoxide hydrolase 2

  • cytosolic epoxide hydrolase

  • epoxide hydratase

  • epoxide hydrolase 2C

  • soluble epoxide hydrolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159157 Anti-inflammatory agent 92 Inhibitor / Unkown
HY-187425 PROTAC sEH degrader-5 Degrader / Unkown
HY-RS04439 EPHX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18273 Ephx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24751 Ephx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ephx2 NCBI NCBI:2053