CRHR2 - corticotropin releasing hormone receptor 2 Gene

Also Known as CRF2; CRFR2; CRF-RB; HM-CRF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1395

About CRHR2

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,651,942-30,700,103 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues and 42 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

CRHR2 Products (7)

mRNA Protein Name
NM_001202482.2 NP_001189411.1 corticotropin-releasing factor receptor 2 isoform 4
XM_047419893.1 XP_047275849.1 corticotropin-releasing factor receptor 2 isoform X2
NM_001202475.1 NP_001189404.1 corticotropin-releasing factor receptor 2 isoform 2 precursor
NM_001202481.1 NP_001189410.1 corticotropin-releasing factor receptor 2 isoform 3
XM_047419892.1 XP_047275848.1 corticotropin-releasing factor receptor 2 isoform X1
NM_001883.5 NP_001874.2 corticotropin-releasing factor receptor 2 isoform 1
NM_001202483.2 NP_001189412.1 corticotropin-releasing factor receptor 2 isoform 5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11329063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRHR2 Protein Structure

HRM

HRM: Hormone receptor domain (38 - 99)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (117 - 355)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

corticotropin-releasing factor receptor 2

  • CRH-R2

CRHR2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85873 CRHR2 Antibody (YA5565) WB, ICC/IF, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Borderline Personality Disorder
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Acute Stress Disorder

  • Traumatic Stress Disorder

  • Stress Disorders, Traumatic, Acute

  • Stress Disorders, Traumatic
Substance Abuse

  • Substance-Related Disorders

  • Substance Abuse Problem
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Eating Disorder

  • Eating Disorders

  • Feeding And Eating Disorders
Generalized Anxiety Disorder

  • Anxiety Generalized
Colitis
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Irritable Bowel Syndrome

  • Irritable Colon

  • Psychogenic Ibs

  • Ibs - [Irritable Bowel Syndrome]

  • Spastic Bowel Syndrome
Personality Disorder

  • Personality Disorders

  • Character Disorder

  • Personality

  • Specific Personality Disorders

  • Enduring Personality Change After Psychiatric Illness
Cystitis

  • Infective Cystitis

  • Urocystitis

  • Pyocystitis
Mood Disorder

  • Mood Disorders

  • Episodic Mood Disorder
Substance Dependence
Post-Traumatic Stress Disorder

  • PTSD

  • Traumatic Neurosis

  • Post Traumatic Stress Disorder

  • Stress Disorders, Post-Traumatic

  • Posttraumatic Stress Disorder

  • Ptsd - [Post Traumatic Stress Disorder]

  • Trauma-Related Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA Agonist 98.71% Unkown
HY-RS03171 CRHR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03172 Crhr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03173 Crhr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CRHR2 VGNC VGNC:27709
Macaca mulatta CRHR2 VGNC VGNC:71492
Canis familiaris CRHR2 VGNC VGNC:39611
Rattus norvegicus CRHR2 RGD RGD:70547
Mus musculus CRHR2 MGD MGI:894312
Felis catus CRHR2 VGNC VGNC:78430
Others CRHR2 NCBI