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CRMP1 - collapsin response mediator protein 1 Gene

Also Known as DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1400

About CRMP1

Cytogenetic location: 4p16.2 Genomic coordinates (GRCh38): 4:5,820,764-5,893,086 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues and 5 paralogues. Biased expression in brain (RPKM 34.7), endometrium (RPKM 8.3) and 8 other tissues.

Summary

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CRMP1 Products (4)

mRNA	Protein	Name
NM_001014809.3	NP_001014809.1	dihydropyrimidinase-related protein 1 isoform 1
NM_001288661.2	NP_001275590.1	dihydropyrimidinase-related protein 1 isoform 3
NM_001288662.1	NP_001275591.1	dihydropyrimidinase-related protein 1 isoform 4
NM_001313.5	NP_001304.1	dihydropyrimidinase-related protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables filamin binding	IPI IPI: Inferred from physical interaction	25358863	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15383276	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	25358863	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in midbody	IDA IDA: Inferred from direct assay	19799413	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRMP1 Protein Structure

Amidohydro_1

0
100
200
300
400
500
572 a.a.

Protein Preferred Names	Protein Names
dihydropyrimidinase-related protein 1	dihydropyrimidinase-like 1

CRMP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRMP1	Q14194	DPYSL3	Homo sapiens	Q14195-2	Validated Y2H	25416956
Intra	CRMP1	Q14194	DPYSL3	Homo sapiens	Q14195-2	Validated Y2H	32296183
Intra	CRMP1	Q14194	DPYSL3	Homo sapiens	Q14195-2	Y2H Array	25416956
Intra	CRMP1	Q14194	DPYSL3	Homo sapiens	Q14195-2	Y2H Prey Pooling	25416956
Intra	CRMP1	Q14194	DPYSL2	Homo sapiens	Q16555	Validated Y2H	32296183
Intra	CRMP1	Q14194	DPYSL2	Homo sapiens	Q16555	Y2H	21900206
Intra	CRMP1	Q14194	DPYSL2	Homo sapiens	Q16555	Y2H Array	24722188
Intra	CRMP1	Q14194	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	CRMP1	Q14194	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	CRMP1	Q14194	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	CRMP1	Q14194	AP3M1	Homo sapiens	Q9Y2T2	Validated Y2H	32296183
Intra	CRMP1	Q14194	AP3M1	Homo sapiens	Q9Y2T2	Y2H Array	25416956
Intra	CRMP1	Q14194	HSP90AA1	Homo sapiens	P07900	Validated Y2H	32814053
Intra	CRMP1	Q14194	HSP90AA1	Homo sapiens	P07900	Y2H Array	32814053
Intra	CRMP1	Q14194	HSP90AA1	Homo sapiens	P07900	Y2H Pooling	32814053
Intra	CRMP1	Q14194	VIM	Homo sapiens	P08670	Y2H	15383276
Intra	CRMP1	Q14194	VIM	Homo sapiens	P08670	Pull Down	15383276
Intra	CRMP1	Q14194	VIM	Homo sapiens	P08670	Y2H	21900206
Intra	CRMP1	Q14194	HTT	Homo sapiens	P42858	Y2H	15383276
Intra	CRMP1	Q14194	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	CRMP1	Q14194	CRYAB	Homo sapiens	P02511	Validated Y2H	32814053
Intra	CRMP1	Q14194	CRYAB	Homo sapiens	P02511	Y2H Pooling	32814053
Intra	CRMP1	Q14194	CRYAB	Homo sapiens	P02511	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CRMP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71547	CRMP1 Protein, Human	Q14194 (M1-G572)	≥ 90%, as determined by reducing SDS-PAGE.

CRMP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82196	CRMP1 Antibody (YA1941)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Sialuria	Sialuria, French Type French Type Sialuria Sialuria French Type Sialic Acid Storage Disease Sialic Acid Storage Disease, Finnish Type Infantile Sialic Acid Storage Disease
Weyers Acrofacial Dysostosis	Curry-Hall Syndrome Weyers Acrodental Dysostosis WAD Acrodental Dysostosis Of Weyers Acrofacial Dysostosis, Weyers Type Acrofacial Dysostosis Of Weyers Curry Hall Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03190	CRMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19672	Crmp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26165	Crmp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CRMP1	VGNC	VGNC:71494
Mus musculus	CRMP1	MGD	MGI:107793
Canis familiaris	CRMP1	VGNC	VGNC:39624
Bos taurus	CRMP1	VGNC	VGNC:27720
Rattus norvegicus	CRMP1	RGD	RGD:2407
Felis catus	CRMP1	VGNC	VGNC:61186
Others	CRMP1	NCBI