APOBEC3D - apolipoprotein B mRNA editing enzyme catalytic subunit 3D Gene

Also Known as A3D; A3DE; ARP6; APOBEC3E; APOBEC3DE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140564

About APOBEC3D

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,021,127-39,033,277 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 5.2), spleen (RPKM 4.6) and 22 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]

APOBEC3D Products (2)

mRNA Protein Name
NM_001363781.1 NP_001350710.1 DNA dC->dU-editing enzyme APOBEC-3D isoform 2
NM_152426.4 NP_689639.2 DNA dC->dU-editing enzyme APOBEC-3D isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in DNA cytosine deamination IDA
IDA: Inferred from direct assay
21835787 GOA
involved in clearance of foreign intracellular DNA IDA
IDA: Inferred from direct assay
20062055 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
21835787 GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: Inferred from direct assay
21835787 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
22915799 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21835787 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3D Protein Structure

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (68 - 197)

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (216 - 384)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

DNA dC->dU-editing enzyme APOBEC-3D

  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

Related Diseases

Diseases Alias
Brachydactyly, Type A3

  • Brachydactyly Type A3

  • BDA3

  • Brachydactyly-Clinodactyly

  • Brachymesophalangy V

  • Brachymesophalangy 5

  • Brachydactyly Clinodactyly
Bone Giant Cell Sarcoma

  • Giant Cell Sarcoma Of The Bone

  • Giant Cell Tumor Of Bone, Malignant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00838 APOBEC3D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOBEC3D MGD MGI:1933111
Others APOBEC3D NCBI