2. Gene
  3. APOBEC3D - apolipoprotein B mRNA editing enzyme catalytic subunit 3D Gene

APOBEC3D - apolipoprotein B mRNA editing enzyme catalytic subunit 3D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as A3D; A3DE; ARP6; APOBEC3E; APOBEC3DE

Gene ID: 140564 | Gene type: protein coding

About APOBEC3D

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,021,127-39,033,277 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 5.2), spleen (RPKM 4.6) and 22 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]

APOBEC3D Products(2)

mRNA Protein Name
NM_001363781.1 NP_001350710.1 DNA dC->dU-editing enzyme APOBEC-3D isoform 2
NM_152426.4 NP_689639.2 DNA dC->dU-editing enzyme APOBEC-3D isoform 1

APOBEC3D Protein Structure

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (68 - 197)

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (216 - 384)

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  • 386 a.a.
Protein Preferred Names Protein Names

DNA dC->dU-editing enzyme APOBEC-3D

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

Related Diseases

Diseases Alias
Brachydactyly, Type A3

Brachydactyly Type A3

BDA3

Brachydactyly-Clinodactyly

Brachymesophalangy V

Brachymesophalangy 5

Brachydactyly Clinodactyly
Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00838 APOBEC3D Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOBEC3D MGD MGI:1933111