F2r - coagulation factor II (thrombin) receptor Gene

Also Known as Cf2r; Par1; ThrR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14062

About F2r

Chromosome 13: 95,738,311-95,754,995 reverse strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 330 orthologues, 16 paralogues and is associated with 54 phenotypes.

Summary

Enables G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including negative regulation of Renin secretion into blood stream; positive regulation of intracellular signal transduction; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including regulation of interleukin-1 beta production; response to lipopolysaccharide; and thrombin-activated receptor signaling pathway. Predicted to be located in several cellular components, including caveola; endosome; and platelet dense tubular network. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; exocrine gland; lung; and thyroid gland. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]

F2r Products (1)

mRNA Protein Name
NM_010169.4 NP_034299.2 proteinase-activated receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
20215560 MGI
enables G-protein alpha-subunit binding IDA
IDA: Inferred from direct assay
20215560 MGI
enables G-protein beta-subunit binding IDA
IDA: Inferred from direct assay
20215560 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dendritic cell homeostasis IMP
IMP: Inferred from mutant phenotype
18305483 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
18305483 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
18305483 MGI
involved in negative regulation of renin secretion into blood stream IDA
IDA: Inferred from direct assay
21859963 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
20215560 MGI
involved in positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
20215560 MGI
acts upstream of or within positive regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
18305483 MGI
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
20215560 MGI
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
20215560 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
20215560 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
18398001 MGI
involved in positive regulation of vasoconstriction IDA
IDA: Inferred from direct assay
21859963 MGI
acts upstream of or within regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18305483 MGI
involved in regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
25645137 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
18305483 MGI
acts upstream of or within thrombin-activated receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18398001 MGI
involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
21414931 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proteinase-activated receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04631 F2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04632 F2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04633 F2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F2r NCBI NCBI:2149