SRXN1 - sulfiredoxin 1 Gene

Also Known as SRX; Npn3; SRX1; C20orf139

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140809

About SRXN1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:646,615-653,200 (from NCBI)

This gene has 1 transcript (splice variant) and 176 orthologues. Ubiquitous expression in adrenal (RPKM 21.6), esophagus (RPKM 17.3) and 25 other tissues.

Summary

Enables oxidoreductase activity, acting on a sulfur group of donors. Involved in response to oxidative stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SRXN1 Products (1)

mRNA Protein Name
NM_080725.3 NP_542763.1 sulfiredoxin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity, acting on a sulfur group of donors IDA
IDA: Inferred from direct assay
15448164 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18172504 GOA
Biological Process GO Annotation Evidence References Source
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
15448164 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15448164 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRXN1 Protein Structure

ParBc

ParBc: ParB-like nuclease domain (44 - 130)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

sulfiredoxin-1

SRXN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRXN1 Q9BYN0 PRDX1 Homo sapiens Q06830
Enzymatic Study
18172504
Intra
SRXN1 Q9BYN0 PRDX1 Homo sapiens Q06830
X-Ray Diffraction
18172504
Intra
SRXN1 Q9BYN0 PRDX1 Homo sapiens Q06830
Fluorescence Spectr
18172504
Cross: Cross-species interaction Intra: Intraspecies interaction

SRXN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P88055 SRXN1 Antibody WB, IHC-P, IHC-F, IF-Tissue

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13800 SRXN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21054 Srxn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27572 Srxn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SRXN1 VGNC VGNC:46822
Bos taurus SRXN1 VGNC VGNC:35304
Macaca mulatta SRXN1 VGNC VGNC:98453
Rattus norvegicus SRXN1 RGD RGD:1307332
Mus musculus SRXN1 MGD MGI:104971
Others SRXN1 NCBI