Fscn1 - fascin actin-bundling protein 1 Gene

Also Known as Fan1; fascin-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14086

Summary

Enables actin filament binding activity. Involved in cell migration and positive regulation of filopodium assembly. Acts upstream of or within actin filament bundle assembly. Located in filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Fscn1 Products (1)

mRNA Protein Name
NM_007984.2 NP_032010.2 fascin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11925108 MGI
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
17671164 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21706053 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament bundle assembly IDA
IDA: Inferred from direct assay
7738015 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
20393565 MGI
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
21685497 MGI
Cellular Component GO Annotation Evidence References Source
located in filopodium IDA
IDA: Inferred from direct assay
15294161 MGI
located in growth cone IDA
IDA: Inferred from direct assay
24720729 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
24720729 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fascin

  • fascin 1

  • singed-like protein

Fscn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fscn1 Q61553 Plxnb3 Mus musculus Q9QY40
Pull Down
21706053
Intra
Fscn1 Q61553 Plxnb3 Mus musculus Q9QY40
Y2H
21706053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05119 FSCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19004 Fscn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25493 Fscn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fscn1 NCBI NCBI:6624