Fem1b - fem 1 homolog b Gene

Also Known as mKIAA0396

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14155

Summary

Predicted to enable death receptor binding activity and ubiquitin ligase-substrate adaptor activity. Acts upstream of or within branching involved in prostate gland morphogenesis; epithelial cell maturation involved in prostate gland development; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Used to study type 2 diabetes mellitus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Apr 2022]

Fem1b Products (1)

mRNA Protein Name
NM_010193.4 NP_034323.1 protein fem-1 homolog B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18816836 MGI
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
34562363 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18816836 MGI
acts upstream of or within epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
18816836 MGI
acts upstream of or within epithelial cell maturation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
18816836 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
21723927 MGI
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
34562363 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21723927 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19796622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein fem-1 homolog B

  • F1A-alpha

  • FEM1-beta

  • fem-1-like death receptor-binding protein alpha

  • fem-1-like in apoptotic pathway protein alpha

  • feminization 1 homolog b

  • mt-Fem

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168865 E3 ligase Ligand 53 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fem1b NCBI NCBI:10116