Fkbp4 - FK506 binding protein 4 Gene

Also Known as p59; FKBP-4; FKBP52; FKPB52; FKBP-52

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14228

Summary

Enables several functions, including Glucocorticoid Receptor binding activity; heat shock protein binding activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within several processes, including Androgen Receptor signaling pathway; embryo implantation; and steroid hormone receptor complex assembly. Located in nucleus. Is expressed in pancreas epithelium. Used to study androgen insensitivity syndrome. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp4 Products (1)

mRNA Protein Name
NM_010219.4 NP_034349.1 peptidyl-prolyl cis-trans isomerase FKBP4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
8341706 MGI
enables GTP binding IDA
IDA: Inferred from direct assay
8341706 MGI
enables heat shock protein binding IDA
IDA: Inferred from direct assay
8341706 MGI
enables nuclear glucocorticoid receptor binding IDA
IDA: Inferred from direct assay
7693550 MGI
enables phosphoprotein binding IDA
IDA: Inferred from direct assay
8341706 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11751894 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17142810 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
17142810 MGI
acts upstream of or within male sex differentiation IMP
IMP: Inferred from mutant phenotype
15831525 MGI
acts upstream of or within prostate gland development IMP
IMP: Inferred from mutant phenotype
17142810 MGI
acts upstream of or within protein-containing complex localization IDA
IDA: Inferred from direct assay
11751894 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
17142810 MGI
acts upstream of or within steroid hormone receptor complex assembly IDA
IDA: Inferred from direct assay
8341706 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8341706 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP4

  • 52 kDa FK506-binding protein

  • 52 kDa FKBP

  • 59 kDa immunophilin

  • FKBP59

  • HBI

  • HSP-binding immunophilin

  • PPIase FKBP4

  • immunophilin FKBP52

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04964 FKBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18819 Fkbp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25309 Fkbp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp4 NCBI NCBI:2288