Gab2 - growth factor receptor bound protein 2-associated protein 2 Gene

Also Known as p97; D130058I17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14389

Summary

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including osteoclast differentiation; phosphatidylinositol-mediated signaling; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to several human genes including GAB2 (GRB2 associated binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gab2 Products (2)

mRNA Protein Name
NM_001162477.1 NP_001155949.1 GRB2-associated-binding protein 2 isoform 2
NM_010248.2 NP_034378.2 GRB2-associated-binding protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
16456001 MGI
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
16456001 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15750601 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
11895767 MGI
acts upstream of or within integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
11895767 MGI
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
15750601 MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
11449275 MGI
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
23401857 MGI
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
11449275 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane raft IDA
IDA: Inferred from direct assay
23478294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GRB2-associated-binding protein 2

  • GRB2-associated binder 2

  • Grb2 associated binder 2

  • PH domain-containing adaptor molecule p97

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05198 GAB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22177 Gab2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28699 Gab2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gab2 NCBI NCBI:9846