CSN2 - casein beta Gene

Also Known as CASB; PDC213

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1447

About CSN2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,955,256-69,965,728 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 86 orthologues. Low expression observed in reference dataset.

Summary

This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential Amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary Minerals, such as calcium and phosphorous. In addition, the C-terminal 14 aa of the protein has antimicrobial activity, especially in preterm milk, displaying Antibacterial activity against S. aureus and Y. enterocolitica. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

CSN2 Products (3)

mRNA	Protein	Name
NM_001302770.2	NP_001289699.1	beta-casein isoform 2 precursor
NM_001385731.1	NP_001372660.1	beta-casein isoform 3 precursor
NM_001891.4	NP_001882.1	beta-casein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	12788072	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31515488	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lactation	IDA IDA: Inferred from direct assay	7979373	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	12788072	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7979373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSN2 Protein Structure

Casein

0
100
200
226 a.a.

Protein Preferred Names	Protein Names
beta-casein

CSN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSN2	P05814	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	CSN2	P05814	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
Intra	CSN2	P05814	FHL2	Homo sapiens	Q14192	Y2H Array	31515488
Intra	CSN2	P05814	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
Intra	CSN2	P05814	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CSN2	P05814	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CSN2	P05814	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CSN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81091	Beta casein Antibody (YA3483)	WB, IP	Human

Related Diseases

Diseases	Alias
Milk Allergy	Milk Allergic Reaction Milk Hypersensitivity Allergy Milk
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Goat Milk Allergy	Capra Hircus Milk Allergy
Cow Milk Allergy	Bos Taurus Milk Allergy Cow'S Milk Protein Sensitivity
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Lactose Intolerance	Lactose Malabsorption Lm - Lactose Malabsorption Alactasia Dairy Product Intolerance Hypolactasia Milk Sugar Intolerance Cow Milk Enteropathy Intolerance Or Malabsorption Of Lactose Lm - [Lactose Malabsorption] Milk Intolerance
Epilepsy, Juvenile Absence 1	Epilepsy, Juvenile Absence, Susceptibility To, 1 EJA1 JAE1 Juvenile Absence Epilepsy 1 Susceptibility To Juvenile Absence Epilepsy 1 Epilepsy, Juvenile Absence, Susceptibility To, Type 1 Absence Epilepsy
Polyposis Syndrome, Hereditary Mixed, 2	HMPS2 Hereditary Mixed Polyposis Syndrome 2 Polyposis Syndrome, Mixed Hereditary 2 Polyposis Syndrome, Hereditary Mixed, Type 2
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03027	COPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03243	CSN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSN2	RGD	RGD:61981
Mus musculus	CSN2	MGD	MGI:88541
Felis catus	CSN2	VGNC	VGNC:78476
Macaca mulatta	CSN2	VGNC	VGNC:71523
Canis familiaris	CSN2	VGNC	VGNC:39665
Bos taurus	CSN2	VGNC	VGNC:27764