Gfra1 - glial cell line derived neurotrophic factor family receptor alpha 1 Gene

Also Known as GFRalpha-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14585

Summary

This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the RET tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or RET. [provided by RefSeq, Jul 2016]

Gfra1 Products (3)

mRNA Protein Name
NM_001285457.3 NP_001272386.1 GDNF family receptor alpha-1 isoform 2 precursor
NM_001410348.1 NP_001397277.1 GDNF family receptor alpha-1 isoform 2 precursor
NM_010279.4 NP_034409.1 GDNF family receptor alpha-1 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23994200 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
11069590 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDNF family receptor alpha-1

  • GDNF receptor alpha 1 (GFRa-1)

  • GDNF receptor alpha 1c

  • GDNF receptor alpha 1d

  • GDNF receptor alpha 1e

  • GDNFR-alpha-1

  • GFR alpha-1

  • TGF-beta-related neurotrophic factor receptor 1

Recombinant Gfra1 Proteins

Cat. No. Product Name Accession Purity
HY-P76360 GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) P97785-2 (D25-S425) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05386 GFRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18390 Gfra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24871 Gfra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfra1 NCBI NCBI:2674