Gnai3 - guanine nucleotide binding protein (G protein), alpha inhibiting 3 Gene

Also Known as Hg1a; Gnai-3; Galphai3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14679

Summary

Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GDP binding activity; and GTPase activating protein binding activity. Predicted to be involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in Golgi apparatus. Is expressed in early conceptus; inner ear; and oocyte. Orthologous to human GNAI3 (G protein subunit alpha i3). [provided by Alliance of Genome Resources, Apr 2022]

Gnai3 Products (1)

mRNA Protein Name
NM_010306.3 NP_034436.1 guanine nucleotide-binding protein G(i) subunit alpha-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
11158953 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
8192889 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8192889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-3

  • g(i) alpha-3

  • guanine nucleotide binding protein, alpha inhibiting 3

  • guanine nucleotide-binding protein G(i) subunit alpha

  • guanine nucleotide-binding protein G(k) subunit alpha

  • heterotrimeric guanine nucleotide-binding protein 1a

Gnai3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gnai3 Q9DC51 Ncl Mus musculus P09405
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05536 GNAI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20413 Gnai3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26922 Gnai3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnai3 NCBI NCBI:2773