Gnaq - guanine nucleotide binding protein, alpha q polypeptide Gene

Also Known as Gq; GqI; Dsk1; Dsk10; Galphaq; 1110005L02Rik; 6230401I02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14682

Summary

Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activator activity; and alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including cranial skeletal system development; Endothelin Receptor signaling pathway; and multicellular organism aging. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; maternal behavior; and neuron development. Located in cell body; dendrite; and membrane. Is expressed in several structures, including central nervous system; gonad; heart; intestine smooth muscle circular layer; and retina. Used to study congestive heart failure and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q). [provided by Alliance of Genome Resources, Apr 2022]

Gnaq Products (1)

mRNA Protein Name
NM_008139.6 NP_032165.3 guanine nucleotide-binding protein G(q) subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein activity IDA
IDA: Inferred from direct assay
20966218 MGI
enables G protein activity IMP
IMP: Inferred from mutant phenotype
26075576 MGI
enables enzyme regulator activity IDA
IDA: Inferred from direct assay
37991948 MGI
enables enzyme regulator activity IMP
IMP: Inferred from mutant phenotype
26075576 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9016340 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9687499 MGI
acts upstream of or within action potential IMP
IMP: Inferred from mutant phenotype
10818132 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10481072 MGI
involved in cranial skeletal system development IGI
IGI: Inferred from genetic interaction
18199583 MGI
acts upstream of or within developmental pigmentation IMP
IMP: Inferred from mutant phenotype
15322542 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
12077299 MGI
involved in endothelin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18199583 MGI
acts upstream of or within forebrain neuron development IMP
IMP: Inferred from mutant phenotype
15340067 MGI
acts upstream of or within glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11438569 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
9687499 MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
20440069 MGI
involved in ligand-gated ion channel signaling pathway IGI
IGI: Inferred from genetic interaction
20440069 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: Inferred from mutant phenotype
26075576 MGI
acts upstream of or within maternal behavior IMP
IMP: Inferred from mutant phenotype
15340067 MGI
acts upstream of or within neuron remodeling IMP
IMP: Inferred from mutant phenotype
9391157 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
20440069 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
20966218 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
20440069 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26075576 MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17194762 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
20440069 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
26075576 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
15340067 MGI
involved in regulation of blood pressure IGI
IGI: Inferred from genetic interaction
26531127 MGI
acts upstream of or within regulation of melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
15322542 MGI
involved in regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
9296496 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
9687499 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
11685543 MGI
located in dendrite IDA
IDA: Inferred from direct assay
11685543 MGI
located in membrane IDA
IDA: Inferred from direct assay
9016340 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
9765251 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
27276689 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(q) subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05539 GNAQ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22188 Gnaq Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28710 Gnaq Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnaq NCBI NCBI:2776