Gnb5 - guanine nucleotide binding protein (G protein), beta 5 Gene

Also Known as GBS; flr; Hg2e; Gbeta5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14697

Summary

Predicted to enable several functions, including G-protein gamma-subunit binding activity; GTPase activating protein binding activity; and chaperone binding activity. Predicted to contribute to GTPase activator activity. Acts upstream of or within G protein-coupled receptor signaling pathway; dark adaptation; and light adaption. Located in several cellular components, including nucleus; photoreceptor inner segment; and photoreceptor outer segment. Is active in presynapse. Is expressed in several structures, including brain; eye; genitourinary system; liver; and lung. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Orthologous to human GNB5 (G protein subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]

Gnb5 Products (2)

mRNA Protein Name
NM_010313.2 NP_034443.1 guanine nucleotide-binding protein subunit beta-5 isoform 1
NM_138719.5 NP_619733.1 guanine nucleotide-binding protein subunit beta-5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15897264 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15897264 MGI
acts upstream of or within dark adaptation IDA
IDA: Inferred from direct assay
23555598 MGI
acts upstream of or within light adaption IDA
IDA: Inferred from direct assay
23555598 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell tip IDA
IDA: Inferred from direct assay
25997951 MGI
is active in dendrite IDA
IDA: Inferred from direct assay
25997951 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15897264 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
27965545 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15897264 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
21766168 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
27965545 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
21766168 MGI
is active in synapse EXP
EXP: Inferred from Experiment
34932372 MGI
is active in synapse IDA
IDA: Inferred from direct assay
34932372 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein subunit beta-5

  • flail

  • flailer

  • guanine nucleotide binding protein, beta 5

  • heterotrimeric guanine nucleotide-binding protein 2e

  • hug

  • transducin beta chain 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05550 GNB5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22190 Gnb5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28712 Gnb5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnb5 NCBI NCBI:10681