Ptgdr2 - prostaglandin D2 receptor 2 Gene

Also Known as Crth2; Gpr44; Grp45

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14764

About Ptgdr2

Chromosome 19: 10,914,524-10,919,875 forward strand.GRCm39:CM001012.3

This gene has 1 transcript (splice variant), 206 orthologues, 15 paralogues and is associated with 11 phenotypes. Broad expression in ovary adult (RPKM 2.6), subcutaneous fat pad adult (RPKM 1.9) and 15 other tissues.

Summary

Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptgdr2 Products (1)

mRNA Protein Name
NM_009962.3 NP_034092.1 prostaglandin D2 receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
12878180 MGI
enables prostaglandin D receptor activity IDA
IDA: Inferred from direct assay
12878180 MGI
enables prostaglandin F receptor activity IDA
IDA: Inferred from direct assay
12878180 MGI
enables prostaglandin J receptor activity IDA
IDA: Inferred from direct assay
12878180 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12878180 MGI
acts upstream of or within calcium-mediated signaling IDA
IDA: Inferred from direct assay
12878180 MGI
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
12878180 MGI
acts upstream of or within negative regulation of male germ cell proliferation IMP
IMP: Inferred from mutant phenotype
25142465 MGI
acts upstream of or within positive regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12878180 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptgdr2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (31 - 313)

7tm_GPCRs

7tm_GPCRs: cd14964 (33 - 57)

7tm_GPCRs

7tm_GPCRs: cd14964 (65 - 86)

7tm_GPCRs

7tm_GPCRs: cd14964 (103 - 125)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (202 - 225)

7tm_GPCRs

7tm_GPCRs: cd14964 (243 - 265)

7tm_GPCRs

7tm_GPCRs: cd14964 (281 - 306)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

prostaglandin D2 receptor 2

  • G-protein coupled receptor 44

  • PGD2 receptor

  • chemoattractant receptor-homologous molecule expressed on TH2 cells

  • prostaglandin D2 receptor CRTH2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15950 AZD1981 Antagonist 99.80% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11370 PTGDR Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11371 PTGDR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11372 Ptgdr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11373 Ptgdr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgdr2 NCBI NCBI:11251