Adgrg1 - adhesion G protein-coupled receptor G1 Gene

Also Known as Cyt28; Gpr56; TM7LN4; TM7XN1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14766

Summary

Enables several functions, including Collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Apr 2022]

Adgrg1 Products (25)

mRNA	Protein	Name
NM_001198894.2	NP_001185823.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403764.1	NP_001390693.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403765.1	NP_001390694.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403766.1	NP_001390695.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403767.1	NP_001390696.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403768.1	NP_001390697.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403769.1	NP_001390698.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403770.1	NP_001390699.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403771.1	NP_001390700.1	adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403772.1	NP_001390701.1	adhesion G-protein coupled receptor G1 isoform b precursor
NM_001403776.1	NP_001390705.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403778.1	NP_001390707.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403779.1	NP_001390708.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403780.1	NP_001390709.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403781.1	NP_001390710.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403782.1	NP_001390711.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403783.1	NP_001390712.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403784.1	NP_001390713.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403785.1	NP_001390714.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403786.1	NP_001390715.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403787.1	NP_001390716.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403788.1	NP_001390717.1	adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403789.1	NP_001390718.1	adhesion G-protein coupled receptor G1 isoform d precursor
NM_001403790.1	NP_001390719.1	adhesion G-protein coupled receptor G1 isoform d precursor
NM_018882.4	NP_061370.2	adhesion G-protein coupled receptor G1 isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	21768377	MGI
enables collagen binding	IDA IDA: Inferred from direct assay	21768377	MGI
enables extracellular matrix binding	IDA IDA: Inferred from direct assay	18509043	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	27068534	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	36453010	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cerebral cortex radial glia-guided migration	IMP IMP: Inferred from mutant phenotype	18509043	MGI
acts upstream of or within cerebral cortex regionalization	IMP IMP: Inferred from mutant phenotype	24531968	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	26880577	MGI
involved in layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	18509043	MGI
involved in negative regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	18509043	MGI
acts upstream of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	24531968	MGI
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	21768377	MGI
acts upstream of or within positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	24531968	MGI
involved in seminiferous tubule development	IMP IMP: Inferred from mutant phenotype	20981830	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in glial limiting end-foot	IDA IDA: Inferred from direct assay	18509043	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
adhesion G-protein coupled receptor G1	G-protein coupled receptor 56 secretin receptor serpentine receptor cyt28

Adgrg1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Adgrg1	Q8K209	Adgrl1	Mus musculus	Q80TR1	Anti Bait CoIP	36453010

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00354	ADGRG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20135	Adgrg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26638	Adgrg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adgrg1	NCBI	NCBI:9289