Lpcat3 - lysophosphatidylcholine acyltransferase 3 Gene

Also Known as C3f; PTG; Lpcat; Lpeat; Lpsat; Oact5; Grcc3f; Lplat5; Mboat5; Moact5

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14792

Summary

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in several processes, including glycerophospholipid metabolic process; plasma lipoprotein particle assembly; and positive regulation of lipid transport. Acts upstream of or within regulation of plasma lipoprotein particle levels. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; endocrine gland; hemolymphoid system; and liver. Orthologous to human LPCAT3 (lysophosphatidylcholine Acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]

Lpcat3 Products (1)

mRNA	Protein	Name
NM_145130.3	NP_660112.1	lysophospholipid acyltransferase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18287005	MGI
enables 1-acylglycerophosphocholine O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	25898003	MGI
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18287005	MGI
enables 1-acylglycerophosphoserine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18287005	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in chylomicron assembly	IMP IMP: Inferred from mutant phenotype	26833026	MGI
involved in endoplasmic reticulum membrane organization	IMP IMP: Inferred from mutant phenotype	28846071	MGI
involved in intestinal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	29395055	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24206663	MGI
involved in negative regulation of response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	24206663	MGI
involved in phosphatidylcholine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	18287005	MGI
involved in phosphatidylethanolamine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	18287005	MGI
involved in phosphatidylserine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	18287005	MGI
involved in positive regulation of intestinal cholesterol absorption	IMP IMP: Inferred from mutant phenotype	26833026	MGI
involved in positive regulation of triglyceride transport	IMP IMP: Inferred from mutant phenotype	25806685	MGI
involved in regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	29395055	MGI
acts upstream of or within regulation of plasma lipoprotein particle levels	IMP IMP: Inferred from mutant phenotype	22511767	MGI
involved in very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	25806685	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	18287005	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lysophospholipid acyltransferase 5	1-acylglycerophosphoserine O-acyltransferase LPC acyltransferase 3 O-acyltransferase domain-containing protein 5 lyso-PC acyltransferase 3 lyso-PE acyltransferase lyso-PS acyltransferase lysophosphatidylethanolamine acyltransferase lysophosphatidyl

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158790	(R)-HTS-3	Inhibitor	99.87%	Unkown
HY-158790A	(S)-HTS-3		/	Unkown
HY-RS07766	LPCAT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19065	Lpcat3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25555	Lpcat3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpcat3	NCBI	NCBI:10162