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Grik2 - glutamate receptor, ionotropic, kainate 2 (beta 2) Gene

Also Known as GluK2; Glur6; Glur-6; Glurbeta2; C130030K03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14806

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]

Grik2 Products (3)

mRNA	Protein	Name
NM_001111268.3	NP_001104738.2	glutamate receptor ionotropic, kainate 2 isoform 1 precursor
NM_001358866.2	NP_001345795.2	glutamate receptor ionotropic, kainate 2 isoform 1 precursor
NM_010349.4	NP_034479.3	glutamate receptor ionotropic, kainate 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glutamate-gated calcium ion channel activity	IDA IDA: Inferred from direct assay	7681676	MGI
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	31474366	MGI
enables glutamate-gated receptor activity	IMP IMP: Inferred from mutant phenotype	16354929	MGI
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	1310861	MGI
enables kainate selective glutamate receptor activity	IGI IGI: Inferred from genetic interaction	1310861	MGI
enables kainate selective glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	9580260	MGI
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	17620617	MGI
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEP IEP: Inferred from expression pattern	17620617	MGI
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	17620617	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12954862	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	22345355	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	9580260	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	9580260	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	15673679	MGI
acts upstream of or within chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	15928066	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	15928066	MGI
involved in detection of cold stimulus involved in thermoception	IMP IMP: Inferred from mutant phenotype	31474366	MGI
acts upstream of or within excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	11985817	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	11069933	MGI
acts upstream of or within inhibitory postsynaptic potential	IGI IGI: Inferred from genetic interaction	10704492	MGI
acts upstream of or within inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	9880586	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	16219388	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10479699	MGI
acts upstream of or within negative regulation of synaptic transmission, glutamatergic	IGI IGI: Inferred from genetic interaction	11985817	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10479699	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	15539395	MGI
acts upstream of or within presynaptic modulation of chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	11985817	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11182092	MGI
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	1310861	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	1310861	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	9490692	MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11182092	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	9580260	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17620617	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17620617	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17620617	MGI
is active in hippocampal mossy fiber to CA3 synapse	EXP EXP: Inferred from Experiment	22345355	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	9580260	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	9580260	MGI
part of kainate selective glutamate receptor complex	IPI IPI: Inferred from physical interaction	12954862	MGI
located in membrane	IDA IDA: Inferred from direct assay	12954862	MGI
is active in mossy fiber rosette	IDA IDA: Inferred from direct assay	27346345	MGI
is active in mossy fiber rosette	IMP IMP: Inferred from mutant phenotype	27346345	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	9141074	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	21734292	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	27346345	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	14724198	MGI
is active in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	27346345	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	11985817	MGI
located in synapse	IDA IDA: Inferred from direct assay	21734292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, kainate 2	gluR beta-2 glutamate receptor 6 glutamate receptor beta-2 proteasome (prosome, macropain) subunit, alpha type 6 pseudogene

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05799	GRIK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05802	GRIK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20416	Grik2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26925	Grik2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grik2	NCBI	NCBI:2898