Grin1 - glutamate receptor, ionotropic, NMDA1 (zeta 1) Gene

Also Known as NR1; GluN1; Nmdar; NMD-R1; NMDAR1; M100174; Rgsc174; GluRzeta1; GluRdelta1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14810

Summary

Enables several functions, including Calmodulin binding activity; cation binding activity; and ion channel activity. Involved in propylene metabolic process. Acts upstream of or within several processes, including chemical synaptic transmission; learning or memory; and regulation of neuron projection development. Located in several cellular components, including dendritic spine; postsynaptic density membrane; and synaptic vesicle membrane. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Grin1 Products (8)

mRNA Protein Name
NM_001177656.2 NP_001171127.1 glutamate receptor ionotropic, NMDA 1 isoform 2
NM_001177657.2 NP_001171128.1 glutamate receptor ionotropic, NMDA 1 isoform 3 precursor
NM_001372558.1 NP_001359487.1 glutamate receptor ionotropic, NMDA 1 isoform 4 precursor
NM_001372559.1 NP_001359488.1 glutamate receptor ionotropic, NMDA 1 isoform 5 precursor
NM_001372560.1 NP_001359489.1 glutamate receptor ionotropic, NMDA 1 isoform 6 precursor
NM_001372561.1 NP_001359490.1 glutamate receptor ionotropic, NMDA 1 isoform 7 precursor
NM_001372562.1 NP_001359491.1 glutamate receptor ionotropic, NMDA 1 isoform 8 precursor
NM_008169.3 NP_032195.1 glutamate receptor ionotropic, NMDA 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NMDA glutamate receptor activity IDA
IDA: Inferred from direct assay
1374164 MGI
enables NMDA glutamate receptor activity IGI
IGI: Inferred from genetic interaction
1374164 MGI
enables NMDA glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
8060614 MGI
enables calcium channel activity IDA
IDA: Inferred from direct assay
1374164 MGI
enables calcium channel activity IGI
IGI: Inferred from genetic interaction
1374164 MGI
enables calcium ion binding IDA
IDA: Inferred from direct assay
15663482 MGI
enables calmodulin binding IDA
IDA: Inferred from direct assay
15663482 MGI
enables glycine binding IMP
IMP: Inferred from mutant phenotype
12586454 MGI
enables monoatomic cation channel activity IGI
IGI: Inferred from genetic interaction
7531804 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8595214 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
11754835 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
10481908 MGI
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
12040087 MGI
acts upstream of or within calcium ion homeostasis IDA
IDA: Inferred from direct assay
7907365 MGI
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
1532151 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
15576450 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
10963597 MGI
acts upstream of or within conditioned taste aversion IMP
IMP: Inferred from mutant phenotype
16101757 MGI
acts upstream of or within excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
14645471 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
15003177 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
8060614 MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
16025111 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
17015831 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
17004940 MGI
acts upstream of or within long-term memory IMP
IMP: Inferred from mutant phenotype
15003177 MGI
acts upstream of or within male mating behavior IMP
IMP: Inferred from mutant phenotype
10481908 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
10700255 MGI
acts upstream of or within monoatomic cation transport IGI
IGI: Inferred from genetic interaction
7531804 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
17077143 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17077143 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
8313466 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
8060614 MGI
acts upstream of or within olfactory learning IMP
IMP: Inferred from mutant phenotype
10700255 MGI
acts upstream of or within pons maturation IMP
IMP: Inferred from mutant phenotype
8313466 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
17803966 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7907365 MGI
acts upstream of or within prepulse inhibition IMP
IMP: Inferred from mutant phenotype
15265649 MGI
involved in propylene metabolic process IDA
IDA: Inferred from direct assay
21795692 MGI
acts upstream of or within protein localization to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
12676993 MGI
acts upstream of or within regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
15745956 MGI
acts upstream of or within regulation of cell communication IMP
IMP: Inferred from mutant phenotype
16299502 MGI
acts upstream of or within regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
15745956 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
10818139 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
8060614 MGI
acts upstream of or within regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10479699 MGI
acts upstream of or within regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16906136 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
15576450 MGI
acts upstream of or within regulation of respiratory gaseous exchange IMP
IMP: Inferred from mutant phenotype
8313466 MGI
acts upstream of or within regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
12657691 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
8980238 MGI
acts upstream of or within response to amphetamine IGI
IGI: Inferred from genetic interaction
21368124 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
15467708 MGI
acts upstream of or within response to morphine IMP
IMP: Inferred from mutant phenotype
18423864 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
12832526 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
10481908 MGI
acts upstream of or within startle response IMP
IMP: Inferred from mutant phenotype
10818139 MGI
acts upstream of or within suckling behavior IMP
IMP: Inferred from mutant phenotype
8313466 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
8313466 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7907365 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
9054942 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
8980238 MGI
Cellular Component GO Annotation Evidence References Source
part of NMDA selective glutamate receptor complex IDA
IDA: Inferred from direct assay
12008020 MGI
part of NMDA selective glutamate receptor complex IPI
IPI: Inferred from physical interaction
9003035 MGI
located in cell surface IDA
IDA: Inferred from direct assay
17229826 MGI
located in cell surface IMP
IMP: Inferred from mutant phenotype
17229826 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12414093 MGI
located in dendrite IDA
IDA: Inferred from direct assay
23395379 MGI
located in dendrite IMP
IMP: Inferred from mutant phenotype
17229826 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
15663482 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16814779 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19726645 MGI
located in membrane IDA
IDA: Inferred from direct assay
8840015 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
1532151 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
15317856 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
19726645 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
11754836 MGI
located in synapse IDA
IDA: Inferred from direct assay
14645471 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
26041915 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
10846156 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
29490264 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, NMDA 1

  • N-methyl-D-aspartate receptor subunit NR1

  • glutamate [NMDA] receptor subunit zeta-1

Orthologs Information

Species Symbol Source ID
Homo sapiens Grin1 NCBI NCBI:2902