Nr3c1 - nuclear receptor subfamily 3, group C, member 1 Gene

Also Known as GR; Grl1; Grl-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14815

About Nr3c1

Chromosome 18: 39,543,598-39,652,474 reverse strand.GRCm39:CM001011.3

This gene has 9 transcripts (splice variants), 280 orthologues, 8 paralogues and is associated with 67 phenotypes. Ubiquitous expression in bladder adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues.

Summary

Enables several functions, including Glucocorticoid Receptor activity; identical protein binding activity; and protein kinase binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including gland development; Glucocorticoid Receptor signaling pathway; and regulation of cellular biosynthetic process. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c1 Products (5)

mRNA Protein Name
NM_001361209.1 NP_001348138.1 glucocorticoid receptor
NM_001361211.1 NP_001348140.1 glucocorticoid receptor
NM_008173.4 NP_032199.3 glucocorticoid receptor
NM_001361212.1 NP_001348141.1 glucocorticoid receptor
NM_001361210.1 NP_001348139.1 glucocorticoid receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15870285 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
7883868 MGI
enables nuclear glucocorticoid receptor activity IDA
IDA: Inferred from direct assay
7914432 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11751894 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20371704 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7883868 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adrenal gland development IMP
IMP: Inferred from mutant phenotype
7628695 MGI
involved in astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
29890290 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
29890290 MGI
acts upstream of or within glucocorticoid metabolic process IMP
IMP: Inferred from mutant phenotype
10509797 MGI
acts upstream of or within mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
12198239 MGI
acts upstream of or within maternal behavior IGI
IGI: Inferred from genetic interaction
23071095 MGI
involved in microglia differentiation IMP
IMP: Inferred from mutant phenotype
29890290 MGI
involved in motor behavior IMP
IMP: Inferred from mutant phenotype
29890290 MGI
involved in neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
29890290 MGI
acts upstream of or within nuclear receptor-mediated glucocorticoid signaling pathway IDA
IDA: Inferred from direct assay
15199138 MGI
involved in nuclear receptor-mediated glucocorticoid signaling pathway IDA
IDA: Inferred from direct assay
25510864 MGI
acts upstream of or within nuclear receptor-mediated glucocorticoid signaling pathway IMP
IMP: Inferred from mutant phenotype
7628695 MGI
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
25510864 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10744634 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10224232 MGI
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17081986 MGI
acts upstream of or within regulation of glucocorticoid biosynthetic process IMP
IMP: Inferred from mutant phenotype
7628695 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
7628695 MGI
involved in synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
29890290 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27686098 MGI
located in cytosol IDA
IDA: Inferred from direct assay
7914432 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
9237103 MGI
located in membrane IDA
IDA: Inferred from direct assay
9237103 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7914432 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr3c1 Protein Structure

GCR

GCR: pfam02155 (26 - 417)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (432 - 509)

NR_LBD_GR

NR_LBD_GR: cd07076 (545 - 791)

  • 0
  • 200
  • 400
  • 600
  • 792 a.a.
Protein Preferred Names Protein Names

glucocorticoid receptor

  • glucocorticoid receptor 1

  • glucocorticoid receptor subtype P

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-RS09544 NR3C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09545 Nr3c1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09546 Nr3c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr3c1 NCBI NCBI:2908