Gucy2c - guanylate cyclase 2c Gene

Also Known as Gcc; GC-C

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14917

Summary

Enables Guanylate Cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system and liver. Used to study abdominal obesity-metabolic syndrome and obesity. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (Guanylate Cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]

Gucy2c Products (2)

mRNA Protein Name
NM_001127318.1 NP_001120790.1 guanylyl cyclase C isoform 1 precursor
NM_145067.3 NP_659504.2 guanylyl cyclase C isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanylate cyclase activity IMP
IMP: Inferred from mutant phenotype
9294128 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17681179 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
9294128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylyl cyclase C

  • STA receptor

  • heat-stable enterotoxin receptor

  • intestinal guanylate cyclase

Recombinant Gucy2c Proteins

Cat. No. Product Name Accession Purity
HY-P78741 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, Fc) Q3UWA6 (V20-M433) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78742 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His) Q3UWA6-1 (V20-M433) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700603 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, N-His, C-Myc) Q3UWA6-1 (V20-M433) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700999 GUCY2C/Guanylyl cyclase C Protein, Mouse (Biotinylated, HEK293, His-Avi) Q3UWA6-1 (V20-M433) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701000 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His-Avi) Q3UWA6-1 (V20-M433) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175615A RSL3-NH2 hydrochloride / Unkown
HY-175615 RSL3-NH2 / Unkown
HY-RS05921 GUCY2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16946 Gucy2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23389 Gucy2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99232 Indusatumab ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gucy2c NCBI NCBI:2984