Hcls1 - hematopoietic cell specific Lyn substrate 1 Gene

Also Known as HS1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15163

Summary

Enables SH3 domain binding activity. Involved in several processes, including positive regulation of myeloid leukocyte differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcls1 Products (1)

mRNA Protein Name
NM_008225.2 NP_032251.2 hematopoietic lineage cell-specific protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables SH3 domain binding IDA
IDA: Inferred from direct assay
9126384 MGI
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
19064729 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7506729 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
19064729 MGI
Biological Process GO Annotation Evidence Références Source
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
10713104 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23001182 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10713104 MGI
involved in positive regulation of granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
23001182 MGI
involved in positive regulation of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
23001182 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23001182 MGI
involved in response to hormone IDA
IDA: Inferred from direct assay
10713104 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10713104 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10713104 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hematopoietic lineage cell-specific protein

  • hematopoietic cell-specific LYN substrate 1

  • lckBP1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06045 HCLS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17702 Hcls1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24166 Hcls1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcls1 NCBI NCBI:3059