Hes5 - hes family bHLH transcription factor 5 Gene

Also Known as bHLHb38

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15208

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including nervous system development; positive regulation of signal transduction; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including nephron morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; paraxial mesenchyme; sensory organ; small intestine; and urinary system. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Hes5 Products (2)

mRNA Protein Name
NM_001370755.1 NP_001357684.1 transcription factor HES-5 isoform 2
NM_010419.4 NP_034549.1 transcription factor HES-5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21259317 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15156153 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18579678 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25535395 MGI
involved in Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
17331197 MGI
involved in S-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
15821257 MGI
involved in astrocyte differentiation IDA
IDA: Inferred from direct assay
15156153 MGI
involved in brain development IMP
IMP: Inferred from mutant phenotype
17331197 MGI
involved in camera-type eye development IMP
IMP: Inferred from mutant phenotype
17331197 MGI
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
17093926 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
15496443 MGI
acts upstream of or within cell maturation IGI
IGI: Inferred from genetic interaction
15496443 MGI
acts upstream of or within central nervous system myelination IMP
IMP: Inferred from mutant phenotype
17006542 MGI
NOT involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17093926 MGI
involved in comma-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of or within establishment of epithelial cell polarity IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within glial cell fate commitment IMP
IMP: Inferred from mutant phenotype
10821751 MGI
acts upstream of inner ear auditory receptor cell differentiation IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
21300049 MGI
involved in metanephric nephron tubule morphogenesis IEP
IEP: Inferred from expression pattern
15465493 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12208538 MGI
involved in negative regulation of astrocyte differentiation IDA
IDA: Inferred from direct assay
12666205 MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
11425898 MGI
involved in negative regulation of inner ear receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
12208538 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
10205173 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10205173 MGI
involved in negative regulation of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
12666205 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17006542 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19050759 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17006542 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
10804175 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
10205173 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10205173 MGI
involved in neuronal stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
11399758 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
17006542 MGI
acts upstream of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17006542 MGI
acts upstream of or within positive regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18579678 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12208538 MGI
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
12208538 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15156153 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19050759 MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15156153 MGI
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
15156153 MGI
acts upstream of or within regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
18048645 MGI
acts upstream of or within regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within regulation of myelination IMP
IMP: Inferred from mutant phenotype
17006542 MGI
acts upstream of or within regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
10804175 MGI
acts upstream of or within regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
10804175 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
19124651 MGI
involved in specification of loop of Henle identity IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of or within telencephalon development IGI
IGI: Inferred from genetic interaction
18579678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor HES-5

  • hairy and enhancer of split 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120782 Yhhu-3792 Activator 99.34% Unkown
HY-120782A Yhhu-3792 hydrochloride Activator / Unkown
HY-172528 Enpp-1/3-IN-1 Inhibitor / Unkown
HY-RS06138 HES5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18944 Hes5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25434 Hes5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hes5 NCBI NCBI:388585