CXADR - CXADR Ig-like cell adhesion molecule Gene

Also Known as CAR; HCAR; CAR4/6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1525

About CXADR

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:17,513,043-17,636,262 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues and 14 paralogues. Ubiquitous expression in skin (RPKM 12.7), duodenum (RPKM 7.3) and 23 other tissues.

Summary

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

CXADR Products (5)

mRNA	Protein	Name
NM_001207063.2	NP_001193992.1	coxsackievirus and adenovirus receptor isoform 2 precursor
NM_001207064.2	NP_001193993.1	coxsackievirus and adenovirus receptor isoform 3 precursor
NM_001207065.2	NP_001193994.1	coxsackievirus and adenovirus receptor isoform 4 precursor
NM_001207066.2	NP_001193995.1	coxsackievirus and adenovirus receptor isoform 5 precursor
NM_001338.5	NP_001329.1	coxsackievirus and adenovirus receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15364909	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12297051	GOA
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12869515	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	14978041	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	12869515	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11734628	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14978041	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	17675666	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	14978041	GOA
involved in epithelial structure maintenance	IMP IMP: Inferred from mutant phenotype	15304526	GOA
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12869515	GOA
involved in homotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	11734628	GOA
involved in neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	15800062	GOA
involved in transepithelial transport	IMP IMP: Inferred from mutant phenotype	15800062	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12297051	GOA
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	15364909	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11316797	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	11734628	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	17675666	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22003382	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14978041	GOA
located in intercalated disc	IDA IDA: Inferred from direct assay	15533241	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	17675666	GOA
located in neuromuscular junction	IDA IDA: Inferred from direct assay	15533241	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9096397	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17675666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXADR Protein Structure

V-set

Ig_2

0
100
200
300
365 a.a.

Protein Preferred Names	Protein Names
coxsackievirus and adenovirus receptor	46 kD coxsackievirus and adenovirus receptor (CAR) protein

CXADR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXADR	P78310	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	CXADR	P78310	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXADR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70049	CXADR Protein, Human (HEK293, His)	P78310/NP_001329.1 (L20-G237)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pharyngoconjunctival Fever	Pharyngo-Conjunctival Fever Adenoviral Pharyngoconjunctivitis Adenovirus Infections, Human
Shipyard Eye	Epidemic Keratoconjunctivitis Ekc
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Hyperparathyroidism, Neonatal Severe	NSHPT Neonatal Severe Primary Hyperparathyroidism Nsph Nhpt Hyperparathyroidism, Neonatal Hyperparathyroidism, Neonatal Severe Primary Neonatal Severe Hyperparathyroidism Hyperparathyroidism, Severe, Neonatal Neonatal Hyperparathyroidism
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Usher Syndrome, Type I	USH1 Usher Syndrome Type 1 Us1 Usher Syndrome, Type 1b Usher Syndrome Type 1e Retinitis Pigmentosa And Congenital Deafness Usher Syndrome, Type Ie USH1E Usher Syndrome, Type 1e Usher Syndrome, Type 1a Usher Syndrome, Type Ib Usher Syndrome Type 1b Usher Syndrome Type Ie Usher Syndrome Type I Usher 1 Usher Syndrome, Type 1 Ush1a Usher Syndrome, Type I, French Variety Usher Syndrome, Type Ia Usher Syndrome 1b USH1B Usher'S Syndrome Type 1b Usher Syndrome Type Ib Ushib
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Rhabdomyosarcoma
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Extrinsic Cardiomyopathy
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16275	Cxadr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03382	CXADR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23594	Cxadr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXADR	VGNC	VGNC:81299
Bos taurus	CXADR	VGNC	VGNC:53521
Felis catus	CXADR	VGNC	VGNC:84870
Rattus norvegicus	CXADR	RGD	RGD:619794
Canis familiaris	CXADR	VGNC	VGNC:56117
Mus musculus	CXADR	MGD	MGI:1201679
Others	CXADR	NCBI