Hoxa2 - homeobox A2 Gene

Also Known as HOX1.11; Hox-1.11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15399

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]

Hoxa2 Products (1)

mRNA Protein Name
NM_010451.2 NP_034581.1 homeobox protein Hox-A2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15634706 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15634706 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15634706 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
9367425 MGI
acts upstream of or within brain segmentation IMP
IMP: Inferred from mutant phenotype
9367425 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
7903600 MGI
acts upstream of or within cell fate determination IMP
IMP: Inferred from mutant phenotype
16221728 MGI
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
23723417 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
10230789 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
10230789 MGI
involved in embryonic skeletal system development IDA
IDA: Inferred from direct assay
25889273 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
15634706 MGI
acts upstream of or within embryonic viscerocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
16221728 MGI
acts upstream of or within middle ear morphogenesis IGI
IGI: Inferred from genetic interaction
15634706 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
15861402 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
9367425 MGI
involved in muscle structure development IDA
IDA: Inferred from direct assay
25889273 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
18164701 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18164701 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
21324897 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15634706 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18164701 MGI
acts upstream of or within osteoblast development IGI
IGI: Inferred from genetic interaction
16751105 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
7903600 MGI
involved in pharyngeal system development IDA
IDA: Inferred from direct assay
25889273 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18787068 MGI
acts upstream of or within rhombomere 2 development IMP
IMP: Inferred from mutant phenotype
7508007 MGI
acts upstream of or within rhombomere 3 development IGI
IGI: Inferred from genetic interaction
7508007 MGI
acts upstream of or within rhombomere 3 morphogenesis IMP
IMP: Inferred from mutant phenotype
10230789 MGI
acts upstream of or within segment specification IMP
IMP: Inferred from mutant phenotype
9367425 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10536059 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Hox-A2

  • homeo box A2

  • homeobox protein Hox-1.11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06297 HOXA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22557 Hoxa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29077 Hoxa2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hoxa2 NCBI NCBI:3199