HOXA2 - homeobox A2 Gene

Also Known as HOX1K; MCOHI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3199

About HOXA2

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,100,354-27,102,683 (from NCBI)

This gene has 2 transcripts (splice variants), 96 orthologues, 42 paralogues and is associated with 3 phenotypes. Broad expression in lung (RPKM 1.2), fat (RPKM 0.8) and 19 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]

HOXA2 Products (1)

mRNA	Protein	Name
NM_006735.4	NP_006726.1	homeobox protein Hox-A2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA2 Protein Structure

Homeobox

0
100
200
300
376 a.a.

Protein Preferred Names	Protein Names
homeobox protein Hox-A2	homeobox protein Hox-1K

Related Diseases

Diseases	Alias
Microtia, Hearing Impairment, And Cleft Palate	Microtia With Or Without Hearing Impairment Bilateral Microtia-Deafness-Cleft Palate Syndrome Bilateral Microtia-Hearing Loss-Cleft Palate Syndrome MCRT MHICP Microtia Without Hearing Impairment
Microtia	Congenital Small Ears Hypoplasia Of Ear
Athabaskan Brainstem Dysgenesis Syndrome	Bosley-Salih-Alorainy Syndrome Navajo Brainstem Syndrome ABDS Human Hoxa1 Syndromes BSAS Athabaskan Brainstem Dysgenesis Bosley Salih Alorainy Syndrome Absd Athabascan Brainstem Dysgenesis Syndrome Narvajo Brainstem Syndrome
Cleft Palate, Cardiac Defects, And Mental Retardation	Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies CPCMR Cleft Palate, Cardiac Defects, And Intellectual Disabillity Cleft Palate, Cardiac Defects, And Intellectual Disability Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies
Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Guttmacher Syndrome Preaxial Deficiency, Postaxial Polydactyly And Hypospadias Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome GUTTS
Sacrum Chordoma
Oculoauricular Syndrome	OCACS Schorderet-Munier-Franceschetti Syndrome Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear Oculoauricular Syndrome, Schorderet Type Oculo-Auricular Syndrome
Combined Oxidative Phosphorylation Deficiency 5	COXPD5 Hypotonia With Lactic Acidemia And Hyperammonemia Combined Oxidative Phosphorylation Defect Type 5 Combined Oxidative Phosphorylation Deficiency, Type 5
Clivus Chordoma	Chordoma Of Clivus
Hand-Foot-Genital Syndrome	Hand-Foot-Uterus Syndrome Hfgs Hfg Syndrome Hfu Syndrome HFG Hfu Hand Foot Uterus Syndrome Hand Foot Genital Syndrome
Branchiootorenal Syndrome	Branchio-Oto-Renal Syndrome Bor Syndrome Branchiootorenal Dysplasia Melnick-Fraser Syndrome Branchiootorenal Spectrum Disorders Branchio-Otorenal Dysplasia Branchio Oto Renal Syndrome Branchiootorenal/Branchiootic Syndrome Bo Syndrome Bor Bos Branchio-Otorenal Syndrome Branchiootic Syndrome Branchiootorenal Syndrome Branchiootic Syndrome 1
Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate	Bamforth-Lazarus Syndrome Bamforth Syndrome Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome Hypothyroidism-Cleft Palate Syndrome BLS Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Monocyte, Dendritic Cell, And Nk Cell Deficiency
Immunodeficiency 32b	IMD32B Immunodeficiency 32b, Monocyte And Dendritic Cell Deficiency, Autosomal Recessive Immunodeficiency 32b, Monocyte, Dendritic Cell, And Natural Killer Cell Deficiency, Autosomal Recessive Irf8 Deficiency, Autosomal Recessive Epstein-Barr Virus Chronic Infection By Epstein-Barr Virus, Susceptibility To Chronic Infection By Autosomal Recessive Irf8 Deficiency Chronic Epstein-Barr Virus Infection Syndrome Caebv Syndrome Chronic Ebv Infection Syndrome Autosomal Recessive Monocyte And Dendritic Cell Deficiency Immunodeficiency, Type 32b Monocyte And Dendritic Cell Deficiency, Autosomal Recessive
Craniofacial Microsomia	Goldenhar Syndrome Hemifacial Microsomia Oculoauriculovertebral Spectrum Oavs Oculo-Auriculo-Vertebral Spectrum CFM Oav Dysplasia Facioauriculovertebral Sequence Fav Sequence First And Second Branchial Arch Syndrome Otomandibular Dysostosis Hfm Oculoauriculovertebral Dysplasia Facio-Auriculo-Vertebral Spectrum Facioauriculovertebral Dysplasia Oculo-Auriculo-Vertebral Dysplasia First Arch Syndrome Oav Dysplasia Goldenhar Disease Expanded Spectrum Hemifacial Microsomia Expanded Spectrum Of Hemifacial Microsomia Oculoauriculovertebral Syndrome Oavd Asymmetric Hypoplasia Of Facial Structures Auriculobranchiogenic Dysplasia Fav First And Second Pharyngeal Arch Syndromes Goldenhar-Gorlin Syndrome Lateral Facial Dysplasia Oav Complex Oral-Mandibular-Auricular Syndrome Unilateral Intrauterine Facial Necrosis Unilateral Mandibulofacial Dysostosis Oav Spectrum Oculoauricular Vertebral Dysplasia Microsomia, Hemifacial Goldenhar Syndrome With Ipsilateral Radial Defect
Orofacial Cleft	Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06297	HOXA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22557	Hoxa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29077	Hoxa2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HOXA2	VGNC	VGNC:29910
Mus musculus	HOXA2	MGD	MGI:96174
Felis catus	HOXA2	VGNC	VGNC:67618
Canis familiaris	HOXA2	VGNC	VGNC:54768
Rattus norvegicus	HOXA2	RGD	RGD:11468112
Macaca mulatta	HOXA2	VGNC	VGNC:108413
Others	HOXA2	NCBI