Hoxb5 - homeobox B5 Gene

Also Known as Hox-2.1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15413

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; endothelial cell differentiation; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; lung; and nervous system. Orthologous to human HOXB5 (homeobox B5). [provided by Alliance of Genome Resources, Apr 2022]

Hoxb5 Products (1)

mRNA	Protein	Name
NM_008268.2	NP_032294.2	homeobox protein Hox-B5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12897140	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12897140	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12897140	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12897140	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	7828847	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	7828847	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	17626057	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	7828847	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	7828847	MGI
acts upstream of or within endothelial cell differentiation	IDA IDA: Inferred from direct assay	12897140	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12897140	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12897140	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	1353982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein Hox-B5	homeo box B5 homeobox protein H24.1 homeobox protein Hox-2.1 homeobox protein Mu-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06309	HOXB5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22559	Hoxb5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29079	Hoxb5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxb5	NCBI	NCBI:3215