Hoxb8 - homeobox B8 Gene

Also Known as Hox-2.4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15416

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of myeloid cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dorsal spinal cord development; embryonic skeletal system morphogenesis; and grooming behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; nervous system; and neural ectoderm. Used to study trichotillomania. Orthologous to human HOXB8 (homeobox B8). [provided by Alliance of Genome Resources, Apr 2022]

Hoxb8 Products (1)

mRNA	Protein	Name
NM_010461.2	NP_034591.1	homeobox protein Hox-B8

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15886193	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	MGI
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	11571641	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	10559485	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	10885747	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	10559485	MGI
acts upstream of or within dorsal spinal cord development	IMP IMP: Inferred from mutant phenotype	10559485	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	10885747	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	10559485	MGI
acts upstream of or within grooming behavior	IMP IMP: Inferred from mutant phenotype	11779477	MGI
involved in negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	11438208	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15886193	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	18430798	MGI
acts upstream of or within skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	11311170	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	11311170	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein Hox-B8	homeo box B8 homeobox protein Hox-2.4

Hoxb8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Hoxb8	P09632	Pbx1	Mus musculus	P41778	Y2H Array	20211142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D2925	dTCOBG		/	Unkown
HY-RS06312	HOXB8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22561	Hoxb8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29081	Hoxb8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxb8	NCBI	NCBI:3218