Hrh1 - histamine receptor H1 Gene

Also Known as H1R; Hir; Bphs; HH1R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15465

About Hrh1

Chromosome 6: 114,374,897-114,460,257 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 186 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues.

Summary

Predicted to enable several functions, including G protein-coupled serotonin receptor activity; calcium ion transmembrane transporter activity; and histamine binding activity. Acts upstream of or within memory; regulation of synaptic plasticity; and visual learning. Predicted to be located in cytosol and plasma membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; stomach; and uterus. Orthologous to human HRH1 (Histamine Receptor H1). [provided by Alliance of Genome Resources, Apr 2022]

Hrh1 Products (7)

mRNA Protein Name
NM_001252643.3 NP_001239572.1 histamine H1 receptor
NM_008285.5 NP_032311.2 histamine H1 receptor
NM_001252642.3 NP_001239571.1 histamine H1 receptor
NM_001317125.2 NP_001304054.1 histamine H1 receptor
NM_001317124.2 NP_001304053.1 histamine H1 receptor
NM_001410031.1 NP_001396960.1 histamine H1 receptor
NM_001317126.2 NP_001304055.1 histamine H1 receptor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
17145090 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17145090 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
17145090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh1 Protein Structure

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (28 - 479)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (28 - 54)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (61 - 87)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (99 - 129)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (141 - 162)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (186 - 215)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (217 - 438)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (447 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

histamine H1 receptor

  • Bordetella pertussis induced histamine sensitization

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03753 DHX34 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03760 DHX8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06359 HRH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06360 Hrh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06361 Hrh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hrh1 NCBI NCBI:3269