Eif2ak1 - eukaryotic translation initiation factor 2 alpha kinase 1 Gene

Also Known as HCR; Hri

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15467

Summary

Enables heme binding activity; protein homodimerization activity; and protein kinase activity. Involved in negative regulation of cell population proliferation and negative regulation of Hemoglobin biosynthetic process. Acts upstream of or within several processes, including macrophage differentiation; protoporphyrinogen IX metabolic process; and regulation of cellular macromolecule biosynthetic process. Located in cytoplasm. Is expressed in alimentary system; central nervous system; liver; nervous system; and spinal cord. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak1 Products (1)

mRNA	Protein	Name
NM_013557.2	NP_038585.2	eukaryotic translation initiation factor 2-alpha kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heme binding	IDA IDA: Inferred from direct assay	10671563	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21223507	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11560503	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	11726526	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within acute inflammatory response	IMP IMP: Inferred from mutant phenotype	17932563	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17932563	MGI
acts upstream of or within macrophage differentiation	IMP IMP: Inferred from mutant phenotype	17932563	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	17932563	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11050009	MGI
involved in negative regulation of hemoglobin biosynthetic process	IDA IDA: Inferred from direct assay	11050009	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	17932563	MGI
involved in protein autophosphorylation	IEP IEP: Inferred from expression pattern	11560503	MGI
acts upstream of or within protoporphyrinogen IX metabolic process	IGI IGI: Inferred from genetic interaction	15931390	MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme	IGI IGI: Inferred from genetic interaction	15931390	MGI
acts upstream of or within regulation of hemoglobin biosynthetic process	IGI IGI: Inferred from genetic interaction	15931390	MGI
acts upstream of or within regulation of translation	IMP IMP: Inferred from mutant phenotype	11726526	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11050009	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 2-alpha kinase 1	heme-controlled repressor heme-regulated eukaryotic initiation factor eIF-2-alpha kinase heme-regulated inhibitor hemin-sensitive initiation factor 2-alpha kinase

Eif2ak1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Eif2ak1	Q9Z2R9	Eif2s1	Mus musculus	Q6ZWX6	Protein Kinase Assay	21223507

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147831	HR-19011		99.64%	Unkown
HY-RS04242	EIF2AK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04243	EIF2AK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22002	Eif2ak1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28519	Eif2ak1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak1	NCBI	NCBI:27102