OGA - Oga O-GlcNAcase Gene

Also Known as Mgea5; Ncoat

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 154968

Summary

Enables beta-N-acetylglucosaminidase activity and Histone Acetyltransferase activity. Involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Located in mitochondrion. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]

OGA Products (1)

mRNA Protein Name
NM_131904.2 NP_571979.1 protein O-GlcNAcase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-N-acetylglucosaminidase activity IDA
IDA: Inferred from direct assay
19004814 RGD
enables histone acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
15485860 RGD
Biological Process GO Annotation Evidence References Source
involved in N-acetylglucosamine metabolic process IMP
IMP: Inferred from mutant phenotype
19139380 RGD
involved in dATP metabolic process IMP
IMP: Inferred from mutant phenotype
17573462 RGD
involved in negative regulation of cardiac muscle adaptation IMP
IMP: Inferred from mutant phenotype
17573462 RGD
involved in negative regulation of protein glycosylation IMP
IMP: Inferred from mutant phenotype
16332679 RGD
involved in positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
16000877 RGD
involved in positive regulation of DNA metabolic process IMP
IMP: Inferred from mutant phenotype
19139380 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16899550 RGD
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
19139380 RGD
involved in positive regulation of calcium ion transport into cytosol IMP
IMP: Inferred from mutant phenotype
16107505 RGD
involved in positive regulation of cell killing IMP
IMP: Inferred from mutant phenotype
19139380 RGD
involved in positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
12242036 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17095531 RGD
involved in positive regulation of mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
19139380 RGD
involved in positive regulation of protein-containing complex disassembly IMP
IMP: Inferred from mutant phenotype
17573462 RGD
involved in positive regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
17573462 RGD
involved in protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
16000877 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
19139380 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein O-GlcNAcase

  • N-acetyl-beta-D-glucosaminidase

  • N-acetyl-beta-glucosaminidase

  • beta-N-acetylhexosaminidase

  • beta-hexosaminidase

  • bifunctional protein NCOAT

  • meningioma expressed antigen 5 (hyaluronidase)

  • meningioma-expressed antigen 5

  • nuclear cytoplasmic O-GlcNAcase a

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-144681 Ceperognastat Inhibitor 99.09% Phase 2
HY-130121 MK-8719 99.30% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12588 Thiamet G Inhibitor 99.99% Unkown
HY-108241 (Z)-PUGNAc 99.13% Unkown
HY-156586 Egalognastat Inhibitor 99.03% Unkown
HY-139431 NAG-thiazoline Inhibitor ≥95.0% Unkown
HY-108032 Hydroxyectoin Inhibitor 98.92% Unkown
HY-131979 TP-040 98.59% Unkown
HY-144682 (2R,4R)-LY3372689 / Unkown
HY-144681A rel-Ceperognastat Inhibitor / Unkown
HY-183557 O-GlcNAcase-IN-6 Inhibitor / Unkown
HY-148240 JNJ-65355394 Inhibitor 99.84% Unkown
HY-161953 O-GlcNAcase-IN-2 Inhibitor / Unkown
HY-185146 O-GlcNAcase-IN-5 Inhibitor / Unkown
HY-176852 O-GlcNAcase-IN-3 Inhibitor / Unkown
HY-181600 O-GlcNAcase-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens OGA NCBI NCBI:10724