Dnaja1 - DnaJ heat shock protein family (Hsp40) member A1 Gene

Also Known as Hsj2; HSJ-2; Nedd7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15502

Summary

The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation‐induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on Other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Dnaja1 Products (3)

mRNA Protein Name
NM_001164671.2 NP_001158143.1 dnaJ homolog subfamily A member 1
NM_001164672.2 NP_001158144.1 dnaJ homolog subfamily A member 1
NM_008298.6 NP_032324.1 dnaJ homolog subfamily A member 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14752510 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15660130 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
15660130 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
15660130 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dnaJ homolog subfamily A member 1

  • DnaJ (Hsp40) homolog, subfamily A, member 1

  • dnaJ protein homolog 2

  • heat shock 40 kDa protein 4

  • heat shock protein J2

  • heat shock protein, Dnaj-like 2

  • neural precursor cell expressed, developmentally down-regulated gene 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116683 116-9e Inhibitor 98.28% Unkown
HY-149911 GY1-22 Inhibitor / Unkown
HY-RS03857 DNAJA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17473 Dnaja1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23931 Dnaja1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnaja1 NCBI NCBI:3301