Hspa4 - heat shock protein 4 Gene

Also Known as 70kDa; APG-2; Hsp110; Hsp70RY; mKIAA4025

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15525

About Hspa4

Chromosome 11: 53,150,641-53,191,284 reverse strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 294 orthologues, 12 paralogues and is associated with 16 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 44.3), adrenal adult (RPKM 3.6) and 28 other tissues.

Summary

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; negative regulation of macromolecule metabolic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in cytoplasm; extracellular exosome; and lipid droplet. Predicted to be active in cytosol and nucleus. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (HSP70) member 4). [provided by Alliance of Genome Resources, Apr 2022]

Hspa4 Products (1)

mRNA Protein Name
NM_008300.3 NP_032326.3 heat shock 70 kDa protein 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hspa4 Protein Structure

HSPA4_NBD

HSPA4_NBD: cd11737 (1 - 383)

PTZ00121

PTZ00121: cl31754 (498 - 744)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 842 a.a.
Protein Preferred Names Protein Names

heat shock 70 kDa protein 4

  • heat shock 70-related protein APG-2

  • heat shock protein, 110 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06428 HSPA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06429 Hspa4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06430 Hspa4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06431 HSPA4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21867 Hspa4l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa4 NCBI NCBI:3308