Htr3a - 5-hydroxytryptamine (serotonin) receptor 3A Gene

Also Known as 5-HT3; 5-HT3A; 5-HT3R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15561

About Htr3a

Chromosome 9: 48,810,513-48,822,399 reverse strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 215 orthologues, 41 paralogues and is associated with 27 phenotypes. Biased expression in colon adult (RPKM 3.9), adrenal adult (RPKM 3.2) and 14 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including chemical synaptic transmission; positive regulation of ion transmembrane transporter activity; and regulation of membrane potential. Predicted to act upstream of or within ion transport. Predicted to be located in several cellular components, including axon; cleavage furrow; and neuronal cell body. Predicted to be part of serotonin-activated cation-selective channel complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; eye; gallbladder; genitourinary system; and gut. Human ortholog(s) of this gene implicated in irritable bowel syndrome. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Apr 2022]

Htr3a Products (2)

mRNA Protein Name
NM_001099644.1 NP_001093114.1 5-hydroxytryptamine receptor 3A isoform 2 precursor
NM_013561.2 NP_038589.2 5-hydroxytryptamine receptor 3A isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20023641 MGI
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
25989383 MGI
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
25989383 MGI
Cellular Component GO Annotation Evidence References Source
part of serotonin-activated cation-selective channel complex IPI
IPI: Inferred from physical interaction
25119048 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr3a Protein Structure

LIC

LIC: TIGR00860 (4 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 3A

  • 5-hydroxytryptamine receptor 3

  • 5HT3 serotonin receptor

  • serotonin receptor 3A

  • serotonin-gated ion channel receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06470 HTR3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06471 Htr3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06472 Htr3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr3a NCBI NCBI:3359