Sdha - succinate dehydrogenase complex flavoprotein subunit A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 157074

Summary

Enables Succinate Dehydrogenase (ubiquinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (Succinate Dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Sdha Products (1)

mRNA Protein Name
NM_130428.1 NP_569112.1 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables succinate dehydrogenase (quinone) activity IMP
IMP: Inferred from mutant phenotype
16520240 RGD
Biological Process GO Annotation Evidence References Source
involved in respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
16520240 RGD
involved in succinate metabolic process IMP
IMP: Inferred from mutant phenotype
16520240 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16520240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

  • flavoprotein subunit of complex II

  • fp

  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12590 SDHA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131453 Mitochondrial respiration-IN-1 Inhibitor / Unkown
HY-180786 DdBIC / Unkown
HY-RS18790 Sdha Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25279 Sdha Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sdha NCBI NCBI:6389