CYP4B1 - cytochrome P450 family 4 subfamily B member 1 Gene

Also Known as CYPIVB1; P-450HP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1580

About CYP4B1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,799,046-46,819,413 (from NCBI)

This gene has 14 transcripts (splice variants), 182 orthologues and 12 paralogues. Biased expression in lung (RPKM 169.4), fat (RPKM 49.5) and 3 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP4B1 Products (5)

mRNA Protein Name
NM_000779.4 NP_000770.2 cytochrome P450 4B1 isoform b
NM_001099772.2 NP_001093242.1 cytochrome P450 4B1 isoform a
NM_001319161.2 NP_001306090.1 cytochrome P450 4B1 isoform c
NM_001319162.2 NP_001306091.1 cytochrome P450 4B1 isoform d
NM_001319163.2 NP_001306092.1 cytochrome P450 4B1 isoform e

CYP4B1 Protein Structure

p450

p450: Cytochrome P450 (47 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
Protein Preferred Names Protein Names

cytochrome P450 4B1

  • cytochrome P450, family 4, subfamily B, polypeptide 1

Related Diseases

Diseases Alias
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-78086 m-Tolualdehyde 99.58% Unkown
HY-106315 4-Ipomeanol Substrate / Unkown
HY-RS03477 CYP4B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-78086R m-Tolualdehyde (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CYP4B1 VGNC VGNC:99874
Rattus norvegicus CYP4B1 RGD RGD:2480
Mus musculus CYP4B1 MGD MGI:103225
Canis familiaris CYP4B1 VGNC VGNC:50363
Felis catus CYP4B1 VGNC VGNC:103324
Others CYP4B1 NCBI