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Irf8 - interferon regulatory factor 8 Gene

Also Known as Myls; ICSBP; IRF-8; Icsbp1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15900

Summary

The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Irf8 Products (2)

mRNA	Protein	Name
NM_001301811.1	NP_001288740.1	interferon regulatory factor 8
NM_008320.4	NP_032346.1	interferon regulatory factor 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18045875	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25331958	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18045875	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	9348310	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	18045875	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	9348310	MGI
involved in dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	12461077	MGI
involved in follicular B cell differentiation	IGI IGI: Inferred from genetic interaction	31000603	MGI
involved in germinal center B cell differentiation	IGI IGI: Inferred from genetic interaction	31000603	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	12393690	MGI
involved in immune response	IMP IMP: Inferred from mutant phenotype	12461077	MGI
acts upstream of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	9348310	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	12393690	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	25331958	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	32741026	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	18045875	MGI
involved in plasmacytoid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	12538667	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IPI IPI: Inferred from physical interaction	18045875	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	9348310	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	31000603	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	9348310	MGI
involved in regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	12461077	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	9348310	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	9348310	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18045875	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interferon regulatory factor 8	interferon consensus sequence binding protein 1 interferon consensus sequence-binding protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175759	EN1033		99.96%	Unkown
HY-RS06912	IRF8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18767	Irf8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25255	Irf8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irf8	NCBI	NCBI:3394