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Id4 - inhibitor of DNA binding 4 Gene

Also Known as Idb4; bHLHb27

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15904

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including gland morphogenesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; immune system; sensory organ; and urinary system. Used to study osteoporosis. Orthologous to human ID4 (inhibitor of DNA binding 4, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]

Id4 Products (1)

mRNA	Protein	Name
NM_031166.3	NP_112443.1	DNA-binding protein inhibitor ID-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20628571	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15280210	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15469968	MGI
acts upstream of astrocyte differentiation	IGI IGI: Inferred from genetic interaction	15882580	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	15469968	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15469968	MGI
acts upstream of or within central nervous system myelination	IMP IMP: Inferred from mutant phenotype	16862533	MGI
acts upstream of or within cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	15469968	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19217292	MGI
acts upstream of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20628571	MGI
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20460371	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	15469968	MGI
acts upstream of or within negative regulation of astrocyte differentiation	IGI IGI: Inferred from genetic interaction	15882580	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20628571	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15882580	MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16862533	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16862533	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15882580	MGI
acts upstream of or within neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15882580	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15882580	MGI
acts upstream of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16862533	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20628571	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15469968	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23786676	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15882580	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20628571	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	23786676	MGI
acts upstream of or within prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	23786676	MGI
acts upstream of or within prostate gland stromal morphogenesis	IMP IMP: Inferred from mutant phenotype	23786676	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	16862533	MGI
acts upstream of or within seminal vesicle morphogenesis	IMP IMP: Inferred from mutant phenotype	23786676	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9418957	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9418957	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA-binding protein inhibitor ID-4	inhibitor of differentiation 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06525	ID4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17871	Id4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24340	Id4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Id4	NCBI	NCBI:3400