DBI - diazepam binding inhibitor, acyl-CoA binding protein Gene

Homo sapiens

Also known as EP; ACBP; ACBD1; CCK-RP

Gene ID: 1622 | Gene type: protein coding

About DBI

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,366,977-119,372,543 (from NCBI)

This gene has 11 transcripts (splice variants), 278 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 97.8), liver (RPKM 93.2) and 25 other tissues.

Summary

This gene encodes diazepam binding inhibitor, a protein that is regulated by Hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DBI Products(12)

mRNA	Protein	Name
NM_001079862.4	NP_001073331.1	acyl-CoA-binding protein isoform 3
NM_001079863.3	NP_001073332.1	acyl-CoA-binding protein isoform 2
NM_001178017.3	NP_001171488.1	acyl-CoA-binding protein isoform 4
NM_001178041.4	NP_001171512.1	acyl-CoA-binding protein isoform 5
NM_001178042.4	NP_001171513.1	acyl-CoA-binding protein isoform 1
NM_001178043.4	NP_001171514.1	acyl-CoA-binding protein isoform 6
NM_001282633.3	NP_001269562.1	acyl-CoA-binding protein isoform 1
NM_001282634.3	NP_001269563.1	acyl-CoA-binding protein isoform 1
NM_001282635.3	NP_001269564.1	acyl-CoA-binding protein isoform 1
NM_001282636.3	NP_001269565.1	acyl-CoA-binding protein isoform 7
NM_001352432.3	NP_001339361.1	acyl-CoA-binding protein isoform 7
NM_020548.9	NP_065438.1	acyl-CoA-binding protein isoform 1

DBI Protein Structure

ACBP

0
87 a.a.

Protein Preferred Names

Protein Names

acyl-CoA-binding protein

GABA receptor modulator

Recombinant DBI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72166	DBI Protein, Human (103a.a, His)	P07108-2 (W2-I104)	≥95%
HY-P74208	DBI Protein, Human (87a.a, His)	P07108-2 (M1-A87)	≥95%

Related Diseases

Diseases

Alias

Schizophrenia 14

Sczd14	Schizophrenia, Susceptibility To, 14
Schizophrenia Susceptibility Locus, Chromosome 2q32-Related

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03547	DBI Human Pre-designed siRNA Set A		/	Unkown
HY-101060	FGIN 1-43		98.96%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DBI	MGD	MGI:94865
Macaca mulatta	DBI	VGNC	VGNC:71741
Canis familiaris	DBI	VGNC	VGNC:39782
Bos taurus	DBI	VGNC	VGNC:27889
Rattus norvegicus	DBI	RGD	RGD:2490
Others	DBI	NCBI

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