Inpp5d - inositol polyphosphate-5-phosphatase D Gene

Also Known as SHIP; SHIP1; SHIP-1; s-SHIP; SIP-145; p150Ship

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16331

Summary

Enables Phosphatase activity and protein domain specific binding activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; negative regulation of bone resorption; and regulation of hemopoiesis. Predicted to be located in actin filament; cortical cytoskeleton; and cytosol. Predicted to colocalize with plasma membrane. Is expressed in several structures, including integumental system; nervous system; respiratory system; skeleton; and spleen. Used to study Paget's disease of bone and systemic lupus erythematosus. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5d Products (6)

mRNA Protein Name
NM_001110192.2 NP_001103662.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2
NM_001110193.2 NP_001103663.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3
NM_010566.3 NP_034696.2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1
NM_001110192.2 NP_001103662.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2
NM_001110193.2 NP_001103663.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3
NM_010566.3 NP_034696.2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10068665 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
10704460 MGI
acts upstream of or within intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
10704460 MGI
acts upstream of or within negative regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
10704460 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
10704460 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
12161749 MGI
acts upstream of or within negative regulation of granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within negative regulation of immune response IMP
IMP: Inferred from mutant phenotype
10704460 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12161749 MGI
acts upstream of or within negative regulation of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within negative regulation of neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
12161749 MGI
acts upstream of or within negative regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within positive regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12161749 MGI
acts upstream of or within positive regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9620849 MGI
acts upstream of or within positive regulation of lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
9620849 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

  • SH2 domain-containing inositol 5'-phosphatase 1

  • SH2 domain-containing inositol phosphatase 1

  • SH2-containing inositol phosphatase SHIP

  • Src homology 2 domain-containing inositol-5-phosphatase

  • inositol polyphosphate-5-phosphatase, 145 kDa

  • phosphatidylin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21142 Inpp5d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06829 INPP5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27659 Inpp5d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp5d NCBI NCBI:3635