IFNLR1 - interferon lambda receptor 1 Gene

Also Known as IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 163702

About IFNLR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,154,168-24,187,289 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 11 paralogues. Broad expression in small intestine (RPKM 5.6), lymph node (RPKM 4.0) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral Infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IFNLR1 Products (3)

mRNA Protein Name
NM_170743.4 NP_734464.1 interferon lambda receptor 1 isoform 1 precursor
NM_173064.3 NP_775087.1 interferon lambda receptor 1 isoform 2
NM_173065.3 NP_775088.1 interferon lambda receptor 1 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12469119 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cellular respiration IMP
IMP: Inferred from mutant phenotype
25930096 GOA
involved in regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
12469119 GOA
Cellular Component GO Annotation Evidence References Source
part of interleukin-28 receptor complex IDA
IDA: Inferred from direct assay
12469119 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNLR1 Protein Structure

Tissue_fac

Tissue_fac: Tissue factor (10 - 111)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

interferon lambda receptor 1

  • CRF2-12

IFNLR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFNLR1 Q8IU57 ANKRD46 Homo sapiens Q86W74-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis 12

  • PSORS12

  • Psoriasis Susceptibility 12

  • Psoriasis 12, Susceptibility To
Zika Virus Congenital Syndrome

  • Zikv Congenital Infection
Immunodeficiency 27a

  • IMD27A

  • Autosomal Recessive Ifngr1 Deficiency

  • Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis

  • Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

  • Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

  • Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency

  • Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

  • Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive

  • Ifngr1 Deficiency, Autosomal Recessive

  • Immunodeficiency 27a, Mycobacteriosis, Ar

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency

  • Msmd Due To Complete Ifngammar1 Deficiency

  • Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency

  • Familial Disseminated Atypical Mycobacterial Infection

  • Interferon Gamma, Receptor 1, Deficiency

  • Immunodeficiency, Type 27a, Mycobacteriosis, Ar

  • Mycobacterial Disease, Mendelian Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06595 IFNLR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174657 Human IFNLR1 mRNA / Unkown
HY-RS18866 Ifnlr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25357 Ifnlr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IFNLR1 MGD MGI:2429859
Canis familiaris IFNLR1 VGNC VGNC:41881
Rattus norvegicus IFNLR1 RGD RGD:1562689
Felis catus IFNLR1 VGNC VGNC:107564
Bos taurus IFNLR1 VGNC VGNC:30061
Macaca mulatta IFNLR1 VGNC VGNC:73415
Others IFNLR1 NCBI