Itm2b - integral membrane protein 2B Gene

Also Known as Bri; Bri2; E25BMM; imBRI2; Bricd2b; D14Sel6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16432

Summary

Enables ATP binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be integral component of organelle membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in central nervous system; pancreas epithelium; and retina. Used to study cerebral amyloid angiopathy. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Apr 2022]

Itm2b Products (1)

mRNA Protein Name
NM_008410.3 NP_032436.1 integral membrane protein 2B precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10679242 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20945367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integral membrane protein 2B

  • immature BRI2

  • integral membrane protein 2B (E25B protein)

  • transmembrane protein BRI

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10192 Amyloid Bri Protein (1-23) Inhibitor / Unkown
HY-RS06984 ITM2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21603 Itm2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28121 Itm2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itm2b NCBI NCBI:9445