Kcnh2 - potassium voltage-gated channel, subfamily H (eag-related), member 2 Gene

Also Known as LQT; ERG1; Lqt2; M-erg; Merg1; merg1a; merg1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16511

Summary

Enables inward rectifier Potassium Channel activity. Acts upstream of or within potassium ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Located in cytoplasm; nuclear envelope; and plasma membrane. Is expressed in several structures, including brain; early conceptus; gonad; heart; and retina. Used to study short QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnh2 Products (2)

mRNA Protein Name
NM_001294162.1 NP_001281091.1 potassium voltage-gated channel subfamily H member 2 isoform 2
NM_013569.2 NP_038597.2 potassium voltage-gated channel subfamily H member 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
9351462 MGI
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
9351446 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
9351446 MGI
acts upstream of or within regulation of heart rate by cardiac conduction IDA
IDA: Inferred from direct assay
10843886 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
9351446 MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization IDA
IDA: Inferred from direct assay
10843886 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 2

  • eag-related protein 1

  • ether-a-go-go-related gene potassium channel 1

  • ether-a-go-go-related protein 1

  • voltage-gated potassium channel subunit Kv11.1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0437 Sotalol hydrochloride 99.93% Unkown
HY-103196 Sotalol Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16697 CID 16020046 Antagonist 99.81% Unkown
HY-N0267 Hypaconitine 99.49% Unkown
HY-B0437AS Sotalol-d6 hydrochloride 98.98% Unkown
HY-B0437S Sotalol-d6 Inhibitor / Unkown
HY-RS07126 KCNH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16857 Kcnh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23298 Kcnh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnh2 NCBI NCBI:3757