Kcnk2 - potassium channel, subfamily K, member 2 Gene

Also Known as TREK-1; A430027H14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16526

Summary

Enables voltage-gated Potassium Channel activity. Acts upstream of or within G protein-coupled receptor signaling pathway; potassium ion transport; and regulation of membrane potential. Located in plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including brain; early conceptus; limb; olfactory epithelium; and secondary oocyte. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk2 Products (10)

mRNA Protein Name
NM_001159850.2 NP_001153322.1 potassium channel subfamily K member 2 isoform 1
NM_001281847.2 NP_001268776.1 potassium channel subfamily K member 2 isoform 3
NM_001281848.1 NP_001268777.1 potassium channel subfamily K member 2 isoform 4
NM_001357119.2 NP_001344048.1 potassium channel subfamily K member 2 isoform 4
NM_001402774.1 NP_001389703.1 potassium channel subfamily K member 2 isoform 5
NM_001402775.1 NP_001389704.1 potassium channel subfamily K member 2 isoform 4
NM_001402776.1 NP_001389705.1 potassium channel subfamily K member 2 isoform 4
NM_001402826.1 NP_001389755.1 potassium channel subfamily K member 2 isoform 6
NM_001402827.1 NP_001389756.1 potassium channel subfamily K member 2 isoform 7
NM_010607.4 NP_034737.2 potassium channel subfamily K member 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
24496152 MGI
enables ligand-gated channel activity IDA
IDA: Inferred from direct assay
23021213 MGI
enables outward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
22726831 MGI
enables potassium ion leak channel activity IDA
IDA: Inferred from direct assay
17110924 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17110924 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
24496152 MGI
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
11560940 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11560940 MGI
involved in chemical synaptic transmission, postsynaptic IDA
IDA: Inferred from direct assay
31728930 MGI
involved in chemical synaptic transmission, postsynaptic IMP
IMP: Inferred from mutant phenotype
31728930 MGI
involved in chloride transmembrane transport IDA
IDA: Inferred from direct assay
23021213 MGI
involved in glutamate secretion IDA
IDA: Inferred from direct assay
23021213 MGI
involved in neuronal action potential IDA
IDA: Inferred from direct assay
22726831 MGI
acts upstream of or within potassium ion transport IDA
IDA: Inferred from direct assay
11560940 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
22354168 MGI
involved in regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
22726831 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
31728930 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
31728930 MGI
located in astrocyte projection IDA
IDA: Inferred from direct assay
23021213 MGI
located in dendrite IDA
IDA: Inferred from direct assay
17110924 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22354168 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
11560940 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium channel subfamily K member 2

  • TREK-1 K(+) channel subunit

  • outward rectifying potassium channel protein TREK-1

  • two pore potassium channel TPKC1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1500 2,2,2-Trichloroethanol Agonist 99.53% Unkown
HY-RS07158 KCNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18069 Kcnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24544 Kcnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnk2 NCBI NCBI:3776