Kif1b - kinesin family member 1B Gene

Also Known as D4Mil1e; KIF1Bp130; KIF1Bp204; A530096N05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16561

Summary

Enables plus-end-directed microtubule motor activity. Involved in anterograde axonal transport; neuromuscular synaptic transmission; and neuron-neuron synaptic transmission. Acts upstream of or within mitochondrion transport along microtubule. Located in cytoplasmic vesicle membrane and mitochondrion. Part of microtubule associated complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb segment; and skeletal musculature. Used to study Charcot-Marie-Tooth disease type 2A1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Orthologous to human KIF1B (Kinesin family member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Kif1b Products (3)

mRNA Protein Name
NM_001290995.1 NP_001277924.1 kinesin-like protein KIF1B isoform c
NM_008441.2 NP_032467.2 kinesin-like protein KIF1B isoform a
NM_207682.2 NP_997565.2 kinesin-like protein KIF1B isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables plus-end-directed microtubule motor activity IDA
IDA: Inferred from direct assay
7528108 MGI
enables plus-end-directed microtubule motor activity IMP
IMP: Inferred from mutant phenotype
11389829 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15975910 MGI
Biological Process GO Annotation Evidence References Source
involved in anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
11389829 MGI
acts upstream of or within mitochondrion transport along microtubule IDA
IDA: Inferred from direct assay
7528108 MGI
involved in mitochondrion transport along microtubule IDA
IDA: Inferred from direct assay
7528108 MGI
involved in neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
11389829 MGI
involved in neuron-neuron synaptic transmission IMP
IMP: Inferred from mutant phenotype
11389829 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
7528108 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
22945799 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
22945799 MGI
NOT located in synaptic membrane IDA
IDA: Inferred from direct assay
11389829 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
11389829 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin-like protein KIF1B

  • N-3 kinesin

  • kinesin heavy chain member 1B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07270 KIF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21616 Kif1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28134 Kif1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif1b NCBI NCBI:23095